产品名称

英文名称：PF-3716556

同义词

928774-43-0、PF-03716556、PF 03716556、PF 3716556、PF-3716556、PF03716556、701L6668UD、(R)-N-(2-hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-carboxamide、Imidazo(1,2-a)pyridine-6-carboxamide, 8-(((4R)-3,4-dihydro-5-methyl-2H-

产品性质

CAS编号：928774-43-0

分子式：C22H26N4O3

分子量：394.47

MDL号：MFCD19690947

PubChem编号：25134521

英文别名：928774-43-0|PF-03716556|PF 03716556|PF 3716556|PF-3716556|PF03716556|701L6668UD|(R)-N-(2-hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-carboxamide|Imidazo(1,2-a)pyridine-6-carboxamide, 8-(((4R)-3,4-dihydro-5-methyl-2H-

规格或纯度：≥98%

英文名称：PF-3716556

生化机理：H +，K + -ATPase抑制剂（在人类重组离子渗漏试验中pIC50 = 6）；在酸性条件下更有效。在体外对H +，K + -ATPase具有高度选择性;Na +，K + -ATPase无活性。还显示了在50个受体和离子通道（IC50>10μM）范围内对H +，K + -ATPase的选择性。在大鼠和狗模型中抑制胃酸分泌。

法律信息：Sold for only research purposes

储存温度：2-8°C储存

运输条件：冰袋运输

备注：卖完停产，不再备货

产品介绍：PF-3716556是一种有效的，选择性的P-CAB钾离子竞争性酸抑制剂，在离子渗透和离子密集检测中，抑制猪H+，K+-ATPase活性，抑制胃酸分泌，对Na+，K+-ATPas没有作用活性，用于治疗胃食管返流疾病。A highly selective H+,K+-ATPase inhibitor that is more potent in acidic conditions.PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na+,K+-ATPase, used for the treatment of gastroesophageal reflux disease.A highly selective H+,K+-ATPase inhibitor that is more potent in acidic conditions.

IUPAC Name：N-(2-hydroxyethyl)-N,2-dimethyl-8-[[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino]imidazo[1,2-a]pyridine-6-carboxamide

INCHI：InChI=1S/C22H26N4O3/c1-14-5-4-6-19-20(14)17(7-10-29-19)24-18-11-16(22(28)25(3)8-9-27)13-26-12-15(2)23-21(18)26/h4-6,11-13,17,24,27H,7-10H2,1-3H3/t17-/m1/s1

InChi Key：YBHKBMJREUZHOV-QGZVFWFLSA-N

Canonical SMILES：CC1=C2C(CCOC2=CC=C1)NC3=CC(=CN4C3=NC(=C4)C)C(=O)N(C)CCO

Isomeric SMILES：CC1=C2[C@@H](CCOC2=CC=C1)NC3=CC(=CN4C3=NC(=C4)C)C(=O)N(C)CCO

WGK Germany：3

PubChem CID：25134521

溶解性：溶于DMSO, 最高浓度 (mg/mL) 39.45, 最高浓度(mM) 100

产品包装