产品名称

英文名称：LY2157299

同义词

Galunisertib、700874-72-2、LY2157299、LY 2157299、LY-2157299、4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide、ly2157299(galunisertib)、UNII-3OKH1W5LZE、Galunisertib (LY2157299)、Galunisertib [USAN]、3OKH1W5LZE、4-[2-(6-

产品性质

CAS编号：700874-72-2

分子式：C22H19N5O

分子量：369.42

PubChem编号：10090485

英文别名：Galunisertib|700874-72-2|LY2157299|LY 2157299|LY-2157299|4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide|ly2157299(galunisertib)|UNII-3OKH1W5LZE|Galunisertib (LY2157299)|Galunisertib [USAN]|3OKH1W5LZE|4-[2-(6-

规格或纯度：≥99%

英文名称：LY2157299

生化机理：LY2157299 is a potent TGFβ RI I (transforming growth factor receptor beta 1) inhibitor.Highly potent, TGF-beta kinase (ALK5)\xa0inhibitor (IC 50 = 56 nM).\xa0Downregulates Smad2 phosphorylation. Increases\xa0VEGF-induced HUVEC cell migration. Enhances anti-neuroblastoma activity of Dinuxtuximab (anti-GD2 antibody) with natural killer cells.

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：LY2157299是有效的TGFβ receptor I (TβRI)抑制剂，IC50为56 nM。Phase 2/3。A potent TGF beta RI inhibitor.LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM. Phase 2/3.A potent TGF beta RI inhibitor.

ALogP：2.4

IUPAC Name：4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide

INCHI：InChI=1S/C22H19N5O/c1-13-4-2-5-18(25-13)21-20(19-6-3-11-27(19)26-21)15-9-10-24-17-8-7-14(22(23)28)12-16(15)17/h2,4-5,7-10,12H,3,6,11H2,1H3,(H2,23,28)

InChi Key：IVRXNBXKWIJUQB-UHFFFAOYSA-N

Canonical SMILES：CC1=NC(=CC=C1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N

Isomeric SMILES：CC1=NC(=CC=C1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N

PubChem CID：10090485

ChEMBL Ligand：CHEMBL2364611

CAS Registry No.：700874-72-2

溶解性：DMSO 74 mg/mL (200.31 mM); Water <1 mg/mL (<1 mM);Ethanol <1 mg/mL (<1 mM)

产品包装