产品名称

英文名称：GW1929

同义词

GW1929、196808-24-9、GW-1929、GW 1929、(S)-2-(2-benzoylphenylamino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid、UNII-X8S066WKF4、X8S066WKF4、CHEMBL434063、CHEBI79992、L-Tyrosine, N-(2-benzoylphenyl)-O-(2-(methyl-2-pyridinylamino)ethyl)-、N-(2-

产品性质

CAS编号：196808-24-9

分子式：C30H29N3O4

分子量：495.57

PubChem编号：6518171

英文别名：GW1929|196808-24-9|GW-1929|GW 1929|(S)-2-(2-benzoylphenylamino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid|UNII-X8S066WKF4|X8S066WKF4|CHEMBL434063|CHEBI79992|L-Tyrosine, N-(2-benzoylphenyl)-O-(2-(methyl-2-pyridinylamino)ethyl)-|N-(2-

规格或纯度：98%

英文名称：GW1929

生化机理：DescriptionIC50 Value 5.0±0.7 mumol/l [1].GW1929 is a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist,in vitro Using Ba2+ (10 mmol/l) as the charge carrier throμgh VDCC, the half-inhibition constants (IC50) for GI 262570, GW 7845, GW 1929, and pioglitazone were 2.0 +/- 0.5, 3.0 +/- 0.5, 5.0 +/- 0.7, and 10.0 +/- 0.8 mumol/l, respectively [1]. PPARγ agonist GW1929significantly decreased TRPC1 and TRPC6 expression in PASMCs [2].in vivo GW1929treatment significantly attenuated the neurological damage in focal cerebral IR injury. Neuroprotective effects of GW1929 were found to be associated with significant reduction in the COX-2, iNOS, MMP-9, TNFα and IL-6 levels [3].GW1929treatment significantly ameliorated cerebral IR induced neurological symptoms, hyperlocomotion, cognitive deficits and hippocampal neuronal damage in CA1 hippocampus region in gerbils. Significant reduction in IR injury in.Potent, selective PPARγ agonist (EC 50 = 8 nM). Decreases glucose, fatty acid and triglyceride levels in vivo . Orally active.

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

IUPAC Name：(2S)-2-(2-benzoylanilino)-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]propanoic acid

INCHI：InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1

InChi Key：QTQMRBZOBKYXCG-MHZLTWQESA-N

Canonical SMILES：CN(CCOC1=CC=C(C=C1)CC(C(=O)O)NC2=CC=CC=C2C(=O)C3=CC=CC=C3)C4=CC=CC=N4

Isomeric SMILES：CN(CCOC1=CC=C(C=C1)C[C@@H](C(=O)O)NC2=CC=CC=C2C(=O)C3=CC=CC=C3)C4=CC=CC=N4

PubChem CID：6518171

ChEMBL Ligand：CHEMBL434063

BindingDB Ligand：50085048

CAS Registry No.：196808-24-9

NURSA Ligand：10.1621/ZGND9Z39K3

RCSB PDB Ligand：EDK

溶解性：25°C DMSO

敏感性：对光敏感

产品包装