产品名称

英文名称：AZD2014

同义词

AZD2014、1009298-59-2、Vistusertib、AZD-2014、Vistusertib [INN]、AZD 2014、3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide、Vistusertib (AZD-2014)、3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzam

产品性质

CAS编号：1009298-59-2

分子式：C25H30N6O3

分子量：462.54

PubChem编号：25262792

英文别名：AZD2014|1009298-59-2|Vistusertib|AZD-2014|Vistusertib [INN]|AZD 2014|3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide|Vistusertib (AZD-2014)|3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzam

规格或纯度：≥98%

英文名称：AZD2014

生化机理：AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity. mTOR kinase inhibitor AZD2014 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays an important role downstream in the PI3K/Akt/mTOR signaling pathway.Novel potent and selective mammalian rapamycin (mTOR)\xa0inhibitor (IC 50 = 2.8 nM). Highly selective against multiple\xa0PI3K\xa0isoforms. Also targets P-Akt (IC 50 = 80 nM) and pS6 (IC 50 = 200 nM). An oral inhibitor with potential anti-neoplastic activ

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：AZD2014是高效mTOR抑制剂，IC50为2.8 nM，对PI3K各亚型(α/β/γ/δ)的抑制性较弱。A selective inhibitor of mTOR kinaseAZD2014 is a novel mTOR inhibitor with IC50 of 2.8 nM; highly selective against multiple PI3K isoforms (α/β/γ/δ).A selective inhibitor of mTOR kinase

ALogP：2.8

IUPAC Name：3-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-N-methylbenzamide

INCHI：InChI=1S/C25H30N6O3/c1-16-14-33-11-9-30(16)23-20-7-8-21(18-5-4-6-19(13-18)24(32)26-3)27-22(20)28-25(29-23)31-10-12-34-15-17(31)2/h4-8,13,16-17H,9-12,14-15H2,1-3H3,(H,26,32)/t16-,17-/m0/s1

InChi Key：JUSFANSTBFGBAF-IRXDYDNUSA-N

Canonical SMILES：CC1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)N5CCOCC5C

Isomeric SMILES：C[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)N5CCOC[C@@H]5C

PubChem CID：25262792

ChEMBL Ligand：CHEMBL2336325

CAS Registry No.：1009298-59-2

溶解性：DMSO 38 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

密度：1.2

折光率：1.61

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH373 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn child

预防措施声明：P280,P321,P405,P501,P264,P260,P270,P330,P203,P301+P316,P318,P319

产品包装