产品名称

英文名称：Sofosbuvir

同义词

GI-7977、L-Alanine, N-((P(S),2'R)-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl)-, 1-methylethyl ester、isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphory、索非布韦

产品性质

CAS编号：1190307-88-0

分子式：C22H29FN3O9P

分子量：529.45

PubChem编号：45375808

别名：索非布韦

英文别名：GI-7977|L-Alanine, N-((P(S),2'R)-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl)-, 1-methylethyl ester|isopropyl ((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphory

规格或纯度：≥99%

英文名称：Sofosbuvir

生化机理：PSI-7977 is an investigational nucleotide analog currently in Phase 2 for treatment of chronic HCV infection. PSI-7851 is a mixture of two similar molecules, PSI-7976 and PSI-7977, which exist in PSI-7851 as isomers of each other. Once inside a liver cell, both molecules are rapidly converted to the same active triphosphate. Given the ability to more easily manufacture PSI-7977, and potentially advantageous in vitro characteristics, PSI-7977 was selected for further clinical development. Antiviral agents

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Sofosbuvir (PSI-7977, GS-7977) 是一种 HCV的NS5B polymerase抑制剂，用于治疗慢性丙型肝炎病毒(HCV)的感染。Sofosbuvir (PSI-7977, GS-7977) is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection.

ALogP：1

IUPAC Name：propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate

INCHI：InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1

InChi Key：TTZHDVOVKQGIBA-IQWMDFIBSA-N

Canonical SMILES：CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3

Isomeric SMILES：C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3

PubChem CID：45375808

CAS Registry No.：1190307-88-0

Wikipedia：Sofosbuvir

ChEMBL Ligand：CHEMBL1259059

DrugBank Ligand：DB08934

DrugCentral Ligand：4811

RCSB PDB Ligand：WG6

溶解性：DMSO

象形图：

信号词：Danger

危险声明：H373 Causes damage to organs through prolonged or repeated exposureH302 Harmful if swallowedH372 Causes damage to organs through prolonged or repeated exposure

预防措施声明：P501,P264,P260,P270,P330,P301+P317,P319

产品包装