产品名称

英文名称：Maropitant

同义词

(2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-methoxybenzyl) quinuclidin-3-amine 、 HY-10053 、 SCHEMBL4191004 、 1-Azabicyclo[2.2.2]octan-3-amine, N-[[5-(1,1-dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-, (2S,3S)- 、 Cerenia Tablets 、 XFA11667 、 DTXSID、(2S,3S)-2-二苯甲基 N-(5-叔丁基-2-甲氧苄基)奎宁环-3-胺 、 (2S,3S)-N-(5-叔丁基-2-甲氧基苄基)-2-(二苯基甲基)奎宁环-3-胺

产品性质

CAS编号：147116-67-4

分子式：C32H40N2O

分子量：468.67

PubChem编号：204108

别名：(2S,3S)-2-二苯甲基 N-(5-叔丁基-2-甲氧苄基)奎宁环-3-胺 | (2S,3S)-N-(5-叔丁基-2-甲氧基苄基)-2-(二苯基甲基)奎宁环-3-胺

英文别名：(2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-methoxybenzyl) quinuclidin-3-amine | HY-10053 | SCHEMBL4191004 | 1-Azabicyclo[2.2.2]octan-3-amine, N-[[5-(1,1-dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-, (2S,3S)- | Cerenia Tablets | XFA11667 | DTXSID

规格或纯度：98%

英文名称：Maropitant

生化机理：Maropitant is a neurokinin (NK1) receptor antagonist. Maropitant is the first NK1 receptor antagonist developed to treat and prevent emesis in dogs. Treatment with 1 mg/kg Maropitant citrate, significantly reduced the size of ulcerative dermatitis (UD) lesions in mice. Intravenous Maropitant decreased (p < 0.05) MAC by 16% (1.74 ± 0.17%). In contrast, epidural administration of either saline or Maropitant did not change (p > 0.05) the MAC (2.17 ± 0.34% and 1.92 ± 0.12%, respectively).

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

IUPAC Name：(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine

INCHI：InChI=1S/C32H40N2O/c1-32(2,3)27-15-16-28(35-4)26(21-27)22-33-30-25-17-19-34(20-18-25)31(30)29(23-11-7-5-8-12-23)24-13-9-6-10-14-24/h5-16,21,25,29-31,33H,17-20,22H2,1-4H3/t30-,31-/m0/s1

InChi Key：OMPCVMLFFSQFIX-CONSDPRKSA-N

Canonical SMILES：CC(C)(C)C1=CC(=C(C=C1)OC)CNC2C3CCN(C2C(C4=CC=CC=C4)C5=CC=CC=C5)CC3

Isomeric SMILES：CC(C)(C)C1=CC(=C(C=C1)OC)CN[C@@H]2[C@@H](N3CCC2CC3)C(C4=CC=CC=C4)C5=CC=CC=C5

PubChem CID：204108

溶解性：DMSO

敏感性：空气及热敏感

熔点：134 °C

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH373 Causes damage to organs through prolonged or repeated exposureH318 Causes serious eye damageH317 May cause an allergic skin reactionH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effects

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P501,P260,P272,P333+P313,P362+P364,P391,P264+P265,P305+P354+P338,P317,P337+P317,P319

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