产品名称

英文名称：Thalidomide

同义词

thalidomide、50-35-1、Thalomid、2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione、Contergan、Distaval、Pantosediv、Softenon、(+/-)-THALIDOMIDE、Kevadon、Sedoval、Theophilcholine、Algosediv、Corronarobetin、Ectiluran、Enterosediv、Gastrinide、Nerosedyn、Neurosedin、Neurosedy、沙利度胺、(±)-2-(2,6-二氧代-3-哌啶基)-1H-异吲哚-1,3 (2H)-二酮、(±)-Thalidomide、N-(2,6-二氧-3-哌啶基)邻苯二甲酰亚胺

产品性质

CAS编号：50-35-1

分子式：C13H10N2O4

分子量：258.23

EC号：200-031-1

MDL号：MFCD00153873

PubChem编号：5426

别名：沙利度胺|(±)-2-(2,6-二氧代-3-哌啶基)-1H-异吲哚-1,3 (2H)-二酮|(±)-Thalidomide|N-(2,6-二氧-3-哌啶基)邻苯二甲酰亚胺

英文别名：thalidomide|50-35-1|Thalomid|2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione|Contergan|Distaval|Pantosediv|Softenon|(+/-)-THALIDOMIDE|Kevadon|Sedoval|Theophilcholine|Algosediv|Corronarobetin|Ectiluran|Enterosediv|Gastrinide|Nerosedyn|Neurosedin|Neurosedy

规格或纯度：≥98%

英文名称：Thalidomide

生化机理：Thalidomide was commonly used therapeutically in the late 1950’s, however, it was withdrawn from the market when it was discovered to cause birth defects. More recent research has found Thalidomide to affect key biochemical pathways yielding antiangiogenic and immunomodulatory activities. This compound has been shown to selectively inhibit TNF α (tumor necrosis factor-α) biosynthesis and basic fibroblast growth factor (bFGF)-induced angiogenesis, induce apoptosis in human monocytes via a cytochrome c-dependent pathway, and to inhibit HIV-1 replication in a monocytoid (U1) line. These new found uses make Thalidomide an extremely valuable research tool.Immunomodulator. Antiproliferative, antiangiogenic and pro-apoptotic.

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：应用沙利度胺已被用于阿尔茨海默病 (AD) 小鼠模型的神经病理学研究。该研究报道，长期服用沙利度胺可引起 β-分泌酶抑制，继而减轻类淀粉样病理。此外，沙利度胺也被用于评价其致畸功能。沙利度胺可影响人胚胎干细胞和诱导多能干细胞分化过程中的内胚层分化和神经发育。A selective inhibitor of TNF alpha biosynthesis shown to have immunomodulatory and antiangeogenic activity.

ALogP：0.3

IUPAC Name：2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

INCHI：InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)

InChi Key：UEJJHQNACJXSKW-UHFFFAOYSA-N

Canonical SMILES：C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O

Isomeric SMILES：C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O

WGK Germany：3

RTECS：TI4375000

PubChem CID：5426

UN Number：2811

Packing Group：I

DrugBank Ligand：DB01041

CAS Registry No.：50-35-1

ChEMBL Ligand：CHEMBL468

Wikipedia：Thalidomide

Immunopaedia Search：thalidomide

Reactome Reaction：R-HSA-9681169

Reactome Drug：R-ALL-9681254

DrugCentral Ligand：2616

溶解性：Soluble in DMSO (>25 mg/ml), cold pyridine, dimethylformamide, dioxane, Acetone, Butyl Acetate, Ethanol (≥2 mg/ml), Ethyl Acetate, Methanol, water (<1 mg/mL ), and 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.6 mg/mL).

熔点：276 °C

象形图：

信号词：Danger

危险声明：H302 Harmful if swallowedH360 May damage fertility or the unborn child

预防措施声明：P280,P405,P501,P264,P270,P330,P203,P301+P317,P318

Class：6.1

Merck Index：9255

个人防护装备：Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品包装