产品名称

英文名称：Bromopyruvic acid

同义词

AS-16146、B1153、3-bromopyruvic acid、bromo-2-oxopropanoic acid、bromopyruvic acid、Bromopyruvic acid, >=97.0% (T)、J-650255、3-bromopyruvate、BPV、CS-5517、J-511892、3-bromo-2-oxopropanoic acid、AKOS015892643、AM84337、EINECS 214-206-5、3-BP、3-BrPA、SCHEMBL8126、Z1079181、3-溴丙酮酸

产品性质

CAS编号：1113-59-3

分子式：C3H3BrO3

分子量：166.96

Beilstein号：1746786

EC号：214-206-5

MDL号：MFCD00002587

PubChem编号：70684

别名：3-溴丙酮酸

英文别名：AS-16146|B1153|3-bromopyruvic acid|bromo-2-oxopropanoic acid|bromopyruvic acid|Bromopyruvic acid, >=97.0% (T)|J-650255|3-bromopyruvate|BPV|CS-5517|J-511892|3-bromo-2-oxopropanoic acid|AKOS015892643|AM84337|EINECS 214-206-5|3-BP|3-BrPA|SCHEMBL8126|Z1079181

规格或纯度：96%

英文名称：Bromopyruvic acid

生化机理：己糖激酶II抑制剂。抗肿瘤剂。抑制谷胱甘肽S-转移酶和SOD。丙酮酸衍生物。引起氧化应激。诱导S和G2 / M细胞周期停滞。显示出抗增殖作用。显示抗肿瘤和抗菌

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：3-Bromopyruvic acid is a brominated derivative of pyruvic acid , which inhibits HXK II (hexokinase II) in cancer cells. As a result of this inhibition the cells are unable to metabolize glucose into ATP directly. Studies conducted on MCF-7 breast cancer cells show that 3-Bromopyruvic acid hydrate reduces the expression of Bcl-2, c-Myc and mutant p53, which are involved in the cell death signal transduction pathway. Alternate studies indicate that 3-Bromopyruvic acid hydrate is a very selective antibiotic, inhibiting the growth of certain yeasts.半胱氨酸残基的亲和标记;核酸和蛋白质之间的交联剂3-Bromopyruvic acid is a brominated derivative of pyruvic acid , which inhibits HXK II (hexokinase II) in cancer cells. As a result of this inhibition the cells are unable to metabolize glucose into ATP directly. Studies conducted on MCF-7 breast cancer cells show that 3-Bromopyruvic acid hydrate reduces the expression of Bcl-2, c-Myc and mutant p53, which are involved in the cell death signal transduction pathway. Alternate studies indicate that 3-Bromopyruvic acid hydrate is a very selective antibiotic, inhibiting the growth of certain yeasts.Affinity label for cysteine residues; Cross-linker between nucleic acids and proteins

IUPAC Name：3-bromo-2-oxopropanoic acid

INCHI：InChI=1S/C3H3BrO3/c4-1-2(5)3(6)7/h1H2,(H,6,7)

InChi Key：PRRZDZJYSJLDBS-UHFFFAOYSA-N

Canonical SMILES：C(C(=O)C(=O)O)Br

Isomeric SMILES：C(C(=O)C(=O)O)Br

WGK Germany：3

RTECS：UZ0840000

PubChem CID：70684

敏感性：对空气敏感、吸湿、对热敏感

熔点：77°C

象形图：

信号词：Danger

危险声明：H314 Causes severe skin burns and eye damage

预防措施声明：P305+P351+P338,P280,P310

个人防护装备：Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品包装