产品名称

英文名称：(-)-Epicatechin

同义词

(-)-Epicatechin、Epicatechin、490-46-0、L-Epicatechin、(-)-Epicatechol、Epicatechol、l-Acacatechin、epi-Catechin、epi-Catechol、(2R,3R)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol、l-Epicatechol、(-)epicatechin、(2R,3R)-(-)-Epicatechin、(2R,3R)-2-(3,4-dihydroxyphenyl)-、(-)-顺式-3,3',4',5,7-五羟基黄烷、(2R,3R)-2-(3,4-二羟基苯基)-3,4-二氢-1(2H)-苯并吡喃-3,5,7-三醇、(-)-表儿茶素、(-)-顺-3,3',4',5,7-五羟基黄烷、(−)-表儿茶素、表儿茶精

产品性质

CAS编号：490-46-0

分子式：C15H14O6

分子量：290.27

Beilstein号：92760

EC号：207-710-1

MDL号：MFCD00075648

PubChem编号：72276

别名：(-)-顺式-3,3',4',5,7-五羟基黄烷|(2R,3R)-2-(3,4-二羟基苯基)-3,4-二氢-1(2H)-苯并吡喃-3,5,7-三醇|(-)-表儿茶素|(-)-顺-3,3',4',5,7-五羟基黄烷|(−)-表儿茶素|表儿茶精

英文别名：(-)-Epicatechin|Epicatechin|490-46-0|L-Epicatechin|(-)-Epicatechol|Epicatechol|l-Acacatechin|epi-Catechin|epi-Catechol|(2R,3R)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol|l-Epicatechol|(-)epicatechin|(2R,3R)-(-)-Epicatechin|(2R,3R)-2-(3,4-dihydroxyphenyl)-

规格或纯度：≥97% (HPLC)

英文名称：(-)-Epicatechin

生化机理：Epicatechin enhances the skeletal muscle structure in heart failure patients and minimizes cardiometabolic risks. It can be used for treating sarcopenia. Epicatechin reduces myostatin and β-galactosidase and increases the level of markers of muscle growth.

来源：Tea

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

产品介绍：表儿茶素是一种黄烷醇化合物。可可产品富含表儿茶素。表儿茶素可增强心力衰竭患者的骨骼肌结构，并最大限度降低心脏代谢风险。它可用于治疗肌肉减少症。表儿茶素可降低肌肉生长抑制素和β-半乳糖苷酶，并提高肌肉生长标志物的水平。抗氧剂,发现于巧克力中产品介绍(-)-Epicatechin 抑制环加氧酶-1 (COX-1) , IC50为 3.2 μM。(-)-Epicatechin 通过阻断 NF-κB 的 p65 亚基的核定位来抑制 IL-1β 诱导的 iNOS 表达。Epicatechin is a flavanol. Cacao products are rich in epicatechin. Epicatechin enhances the skeletal muscle structure in heart failure patients and minimises the cardiometabolic risks. It can be used for treating sarcopenia. Epicatechin reduces myostatin and β-galactosidase and increases the level of markers of muscle growth.Antioxidant found in chocolate.Product description(-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB.Application(−)-Epicatechin (EC) has been usedas an antioxidant to downregulate nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase and improve insulin sensitivity in in vivo (high fat-fed mice) and in vitro (HepG2 cells) studiesto study its effect on blood pressure, nitric oxide synthase (NOS) activity and anxiety-like behavior on borderline hypertensive rat (BHR) modelsto test its effect on neuronal survival in the hippocampus of middle-aged rats on swimming training, under oxidative stressto study its antioxidant activity in dark chocolateas a characteristic compound in polyphenols analysis

PubChem SID：488184683

IUPAC Name：(2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol

INCHI：InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m1/s1

InChi Key：PFTAWBLQPZVEMU-UKRRQHHQSA-N

Canonical SMILES：C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O

Isomeric SMILES：C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O

WGK Germany：3

RTECS：KB3745000

关联CAS：490-46-0,17334-50-8

PubChem CID：72276

MeSH Entry Terms：(+)-Catechin;(+)-Cyanidanol;(+)-Cyanidanol-3;(-)-Epicatechin;(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,5,7-chromanetriol;2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-cis)-;3,3',4',5,7-Flavanpentol;Catechin;Catechinic Acid;Catechuic Acid;

溶解性：Soluble in acetonewater (11, 10 mg/ml), DMSO (100 mM), methanol, DMF (~12.5 mg/ml), and water (partly)., Soluble in acetonewater (11, 10 mg/ml), DMSO (100 mM), methanol, DMF (~12.5 mg/ml), and water (partly).,

密度：1.593

敏感性：对热和空气敏感

比旋光度：-62° (C=0.1,MeOH)

熔点：240°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

产品包装