产品名称

英文名称：Teniposide

同义词

4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside)、Vehem、VM26、VM-26、(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-(2-thienyl)-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxy-phenyl、替尼泊甙

产品性质

CAS编号：29767-20-2

分子式：C32H32O13S

分子量：656.65

MDL号：MFCD00866516

PubChem编号：452548

别名：替尼泊甙

英文别名：4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside)|Vehem|VM26|VM-26|(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-(2-thienyl)-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxy-phenyl

规格或纯度：≥98%

英文名称：Teniposide

生化机理：Teniposide is a glycoside-derivative of podophyllotoxin, has cytostatic effect. Teniposide inhibits Topo II(topoisomerase II)while induces apoptosis.Topoisomerase II inhibitor. A podophyllotoxin derivative. Induces apoptosis in vitro and in vivo .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：20mg卖完停产，不再备货 如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：A derivative of podophyllotoxin that has shown cytostatic effect & inhibition of topoisomerase II.A derivative of podophyllotoxin that has shown cytostatic effect & inhibition of topoisomerase II.

ALogP：1.2

PubChem SID：488189868

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488189868

IUPAC Name：(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-thiophen-2-yl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one

INCHI：InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1

InChi Key：NRUKOCRGYNPUPR-QBPJDGROSA-N

Canonical SMILES：COC1=CC(=CC(=C1O)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)OC6C(C(C7C(O6)COC(O7)C8=CC=CS8)O)O

Isomeric SMILES：COC1=CC(=CC(=C1O)OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](C4=CC5=C(C=C24)OCO5)O[C@H]6[C@@H]([C@H]([C@H]7[C@H](O6)CO[C@H](O7)C8=CC=CS8)O)O

PubChem CID：452548

DrugBank Ligand：DB00444

CAS Registry No.：29767-20-2

ChEMBL Ligand：CHEMBL452231

Wikipedia：Teniposide

ChEBI：CHEBI75988

RCSB PDB Ligand：9TP

DrugCentral Ligand：2590

溶解性：Soluble in acetone, dimethyl formamide, methanol (slightly), and DMSO (10 mg/ml). Insoluble in water.

敏感性：对热敏感

比旋光度：-111° (C=1,CHCl3MeOH=91)

熔点：247 °C(dec.)

象形图：

信号词：Danger

危险声明：H350 May cause cancer

预防措施声明：P280,P405,P501,P203,P318

Merck Index：9145

产品包装