产品名称

英文名称：Troglitazone

同义词

troglitazone、97322-87-7、Rezulin、Romglizone、Prelay、CS-045、Romozin、Noscal、Rezulin (TN)、troglitazona、troglitazonum、CS 045、GR 92132X、CCRIS 8969、GR92132X、CI 991、CI-991、GR-92132X、CHEBI9753、5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolid、曲格列酮、特洛格列酮、5-[4-[(6-羟基-2,5,7,8-四甲基苯并二氢吡喃-2-基)甲氧基]苄基]噻唑烷-2,4-二酮

产品性质

CAS编号：97322-87-7

分子式：C24H27NO5S

分子量：441.54

MDL号：MFCD00878416

PubChem编号：5591

别名：曲格列酮|特洛格列酮|5-[4-[(6-羟基-2,5,7,8-四甲基苯并二氢吡喃-2-基)甲氧基]苄基]噻唑烷-2,4-二酮

英文别名：troglitazone|97322-87-7|Rezulin|Romglizone|Prelay|CS-045|Romozin|Noscal|Rezulin (TN)|troglitazona|troglitazonum|CS 045|GR 92132X|CCRIS 8969|GR92132X|CI 991|CI-991|GR-92132X|CHEBI9753|5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolid

规格或纯度：≥96%

英文名称：Troglitazone

生化机理：Troglitazone has been shown to be a potent antiproliferative and apoptosis inducer. This compound has displayed a capacity to inhibit growth of HCC cells via G1 phase cell cycle arrest throμgh hypophosphorylation of Rb (retinoblastoma) protein and an increase of the cyclin-dependent kinase inhibitors, p21 and p27 proteins. In addition, Troglitazone has been reported to have profound antioxidant and antiinflammatory effects, and found to suppress L-type and receptor operated Ca2+ channel and PKC (protein kinase C). Experiments have shown Troglitazone to bind and activate PPARγ(peroxisome proliferator-activated receptor γ). PPARγ is mainly expressed in adipose tissue, one of the target tissues for insulin, but has subsequently been found to be expressed in vascular smooth muscle cells, endothelial cells, macrophages, and some cancer cells.Potent, selective PPAR-γ receptor agonist (EC 50 = 780 nM). No activity at PPAR-α or PPAR-δ (up to 10 mM). Orally active. Antidiabetic and anticancer agent. Active in vivo and in vitro .

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Troglitazone(CS-045)是PPARγ激动剂，具有抗炎抗癌活性。A potent antiproliferative, apoptosis inducer, antioxidant, and antiinflammatory agentTroglitazone(CS-045), PPARγ agonist, is an anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity.A potent antiproliferative, apoptosis inducer, antioxidant, and antiinflammatory agent

IUPAC Name：5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

INCHI：InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)

InChi Key：GXPHKUHSUJUWKP-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C

Isomeric SMILES：CC1=C(C2=C(CCC(O2)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C(=C1O)C)C

PubChem CID：5591

ChEBI：CHEBI9753

CAS Registry No.：97322-87-7

ChEMBL Ligand：CHEMBL408

DrugBank Ligand：DB00197

BindingDB Ligand：50085045

Wikipedia：Troglitazone

NURSA Ligand：10.1621/1OKKOA3GMJ

DrugCentral Ligand：2767

溶解性：Soluble in ethanol (>25 mg/ml) at 50 °C, DMSO (>25 mg/ml), DMF (30 mg/ml), DMSOPBS (16, pH 7.2) (0.1 mg/ml), and water (0.1 mg/ml) at 25 °C.

敏感性：对空气敏感，对热敏感

熔点：177 °C

Merck Index：9769

产品包装