IMD 0354,IKKβ抑制剂

产品分类

研究领域/信号传导/信号通路/核信号

产品名称

中文名称：IMD 0354,IKKβ抑制剂

英文名称：IMD 0354

同义词

CS-4922、AKOS017344958、NCGC00165811-02、NSC800773、NSC-800773、SMR004702969、HMS3269F13、HMS3677J21、IKK-2-inhibitor-V、HMS3651D21、N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide、s2864、SB19541、SCHEMBL129165、BCP0726000026、BCP22358、C77350、DTXSID50243、IKK-2 抑制剂 V

产品性质

CAS编号：978-62-1

分子式：C15H8ClF6NO2

分子量：383.67

MDL号：MFCD00218820

PubChem编号：5081913

规格或纯度：≥99%

英文名称：IMD 0354

生化机理：有力的，选择性的细胞渗透性IKKβ抑制剂（IC 50 = 250 nM）。阻止IκBα磷酸化并阻止NF-κBp65核移位。降低IL-1β和MCP-1的产生。显示出抗增殖作用。在体内显示抗炎作用。IMD-0354 acts as an inhibitor by inhibiting the phosphorylation of the NF-κB (nuclear factor) and its translocation into the nucleus. It blocks IκBα phosphorylation (IC50 ~ 250 nM). Cardioprotectant, that reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes. IMD-0354 affects angiogenesis, which has been observed in human umbilical vein endothelial cells. It prevents tube formation and migration of the cells. In vivo studies also prove that IMD-0354 inhibits retinal vessel growth. IMD-0354 also acts as an inhibitor of Aquaporin 4 (AQP4) inhibitor (IC50 0.2μM) with no inhibitory potency to IKK-β.

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：产品介绍IMD-0354 (IKK2 Inhibitor V) 是一种选择性 IKKβ 抑制剂，抑制 NF-κB 活性。IMD0354 抑制 TNF-α 诱导的 NF-κB 转录活性，IC50 为 1.2 μM。applicationIMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.

IUPAC Name：N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide

INCHI：InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)

InChi Key：CHILCFMQWMQVAL-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O

WGK Germany：3

PubChem CID：5081913

溶解性：DMSO 10 mg/mL Water <1 mg/mL Ethanol 77 mg/mL

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

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