产品名称

英文名称：Epothilone B

同义词

Epothilone B、Patupilone、152044-54-7、(-)-Epothilone B、Epo B、EPO906、Epothilon B、EPO 906、Patupilone [INN]、EPO 906A、GNF-PF-193、Epithilone b、Patupilone (Epothilone B)、CHEBI31550、EPO-906、UEC0H0URSE、EPO-906A、(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,1

产品性质

CAS编号：152044-54-7

分子式：C27H41NO6S

分子量：507.68

MDL号：MFCD02101921

PubChem编号：448013

英文别名：Epothilone B|Patupilone|152044-54-7|(-)-Epothilone B|Epo B|EPO906|Epothilon B|EPO 906|Patupilone [INN]|EPO 906A|GNF-PF-193|Epithilone b|Patupilone (Epothilone B)|CHEBI31550|EPO-906|UEC0H0URSE|EPO-906A|(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,1

规格或纯度：≥98% (HPLC)

英文名称：Epothilone B

生化机理：Epothilone B (EPO906, Patupilone) is a Taxol-like microtubule-stabilizing agent with EC0.01 of 1.8 μM. Epothilone B, microtubule stabilization agent that promotes tubulin polymerization and induces G2-M cell cycle arrest (EC50 = 3 - 92 nM). Epothilone B potently inhibits a variety of human cancer cell lines (IC50 values are 0.13 - 0.64 nM), including MDR cells overexpressing the P-glycoprotein efflux pump. Epothilone B exhibits potent anticancer activity in numerous human tumor xenografts in vivo.Microtubule-stabilizing agent. Analog of Epothilone A and D. Displays highest efficacy in class III β-tubulin overexpressing malignancies. Inhibits Paclitaxel -resistant cell lines. Shows antitumor effects in vivo.

应用：（ - ）-埃博霉素B是一种微管（MT）的稳定药物,来自于天然粘细菌Sorangium cellulosum，是大环内酯类抗肿瘤因子。EpoB与EpoA相似的生物学特性。然而，在有效对抗P -糖蛋白表达多药耐药（MDR）细胞(IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells)，EpoB药效10倍于EpoA。（ - ）-埃博霉素B类似于紫杉醇，并在细胞生长中可替代紫杉醇。 EpoB导致细胞周期停滞(IC50 = 3.5 nM).。

储存温度：避光,-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：（ - ）-埃博霉素B是一种微管（MT）的稳定药物,来自于天然粘细菌Sorangium cellulosum，是大环内酯类抗肿瘤因子。EpoB与EpoA相似的生物学特性。然而，在有效对抗P -糖蛋白表达多药耐药（MDR）细胞(IC50 = 2 nM for MDR CCRF-CEM/VBL100 cells)，EpoB药效10倍于EpoA。（ - ）-埃博霉素B类似于紫杉醇，并在细胞生长中可替代紫杉醇。 EpoB导致细胞周期停滞(IC50 = 3.5 nM).。

ALogP：4.2

IUPAC Name：(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

INCHI：InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1

InChi Key：QXRSDHAAWVKZLJ-PVYNADRNSA-N

Canonical SMILES：CC1CCCC2(C(O2)CC(OC(=O)CC(C(C(=O)C(C1O)C)(C)C)O)C(=CC3=CSC(=N3)C)C)C

Isomeric SMILES：C[C@H]1CCC[C@@]2([C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C)C

WGK Germany：3

PubChem CID：448013

密度：1.136

敏感性：对光敏感

比旋光度：-36° (C=0.2,MeOH)

熔点：94 °C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH335 May cause respiratory irritationH301 Toxic if swallowedH341 Suspected of causing genetic defectsH351 Suspected of causing cancerH318 Causes serious eye damageH317 May cause an allergic skin reactionH400 Very toxic to aquatic lifeH410 Very toxic to aquatic life with long lasting effectsH300 Fatal if swallowedH310 Fatal in contact with skinH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P261,P273,P280,P302+P352,P321,P405,P501,P264,P260,P281,P271,P270,P304+P340,P403+P233,P272,P333+P313,P362+P364,P391,P330,P262,P361+P364,P203,P264+P265,P301+P316,P305+P354+P338,P318,P317,P332+P317,P316,P319

Merck Index：3628

产品包装