产品名称

英文名称：TCS 359

同义词

301305-73-7、TCS 359、Flt-3 inhibitor、2-(3,4-dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide、TCS-359、2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide、2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-te、2-(3,4-二甲氧基苯甲酰胺基)-4,5,6,7-四氢苯并[b]噻吩-3-甲酰胺、Flt-3抑制剂

产品性质

CAS编号：301305-73-7

分子式：C18H20N2O4S

分子量：360.43

MDL号：MFCD00617269

PubChem编号：1048845

别名：2-(3,4-二甲氧基苯甲酰胺基)-4,5,6,7-四氢苯并[b]噻吩-3-甲酰胺|Flt-3抑制剂

英文别名：301305-73-7|TCS 359|Flt-3 inhibitor|2-(3,4-dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide|TCS-359|2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide|2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-te

规格或纯度：≥99%

英文名称：TCS 359

生化机理：DescriptionIC50 Value 42 nM [1]TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM.in vitro TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent inhibitor of FLT3 with IC50 of 42 nM. TCS 359 inhibits MV4-11 proliferation with IC50 of 340 nM. TCS 359 is highly selective for FLT3 against a panel of kinases [1].in vivo N/AToxicity N/AClinical trial N/A.Potent FLT3 receptor tyrosine kinase inhibitor (IC 50 = 42 nM). Selective over 22 other kinases. Shows antiproliferative effects (IC 50 = 340 nM for Human acute myelocytic leukemia MV4-11 cells).

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

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产品介绍：TCS 359 是一种 2-酰基氨基噻吩-3-甲酰胺，是一种有效的选择性 FLT3 抑制剂，IC50 为 42 nM。TCS 359 抑制 MV4-11 细胞增殖，IC50 为 340 nM。具有细胞渗透性的噻吩甲酰胺化合物，可作为有效的，ATP竞争性高选择性Flt-3抑制剂。TCS 359, a 2-acylaminothiophene-3-carboxamide, is a potent and selective FLT3 inhibitor with an IC50 of 42 nM. TCS 359 inhibits MV4-11 cell proliferation with an IC50 of 340 nM.A cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor

IUPAC Name：2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

INCHI：InChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)

InChi Key：FSPQCTGGIANIJZ-UHFFFAOYSA-N

Canonical SMILES：COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC

Isomeric SMILES：COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC

WGK Germany：3

PubChem CID：1048845

ChEMBL Ligand：CHEMBL210833

CAS Registry No.：301305-73-7

溶解性：DMSO 15 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

敏感性：对光敏感

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US), Eyeshields, Gloves

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