产品名称

英文名称：Palifosfamide

同义词

Palifosfamide、31645-39-3、Ifosfamide mustard、Isophosphamide mustard、Isophosphoramide mustard、Ifosforamide mustard、bis(2-chloroethylamino)phosphinic acid、Phosphorodiamidic acid, N,N'-bis(2-chloroethyl)-、ZIO-201、NSC 297900、NSC-297900、CHEBI80566、N,N'-Bis(2-c

产品性质

CAS编号：31645-39-3

分子式：C4H11Cl2N2O2P

分子量：221.02

PubChem编号：100427

英文别名：Palifosfamide|31645-39-3|Ifosfamide mustard|Isophosphamide mustard|Isophosphoramide mustard|Ifosforamide mustard|bis(2-chloroethylamino)phosphinic acid|Phosphorodiamidic acid, N,N'-bis(2-chloroethyl)-|ZIO-201|NSC 297900|NSC-297900|CHEBI80566|N,N'-Bis(2-c

规格或纯度：≥98%

英文名称：Palifosfamide

生化机理：DescriptionIC50 Value 0.5-1.5mg/ml [1]Palifosfamide (Zymafos or ZIO-201) references a novel composition (tris formulation) that is the functional active metabolite of ifosfamide (IFOS), a bi-functional DNA alkylator being investigated as a potential therapy for the treatment of soft tissue sarcoma (STS).in vitro Palifosfamide lysine was cytotoxic against all the cell lines tested with the IC(50) ranging from 0.5 to 1.5 microg/ml except for OS222, which had an IC(50) of 7 microg/ml [1].in vivo Dose response, route and schedule of administration, and interaction with docetaxel or doxorubicin were investigated in NCr-nu/nu mice bearing established orthotopic mammary MX-1 tumor xenografts. Oral activity was investigated in P388-1 leukemia in CD2F1 mice. Oral and intraperitoneal bioavailabilities were compared in Sprague-Dawley rats. Stabilized palifosfamide administered by optimized regimens suppressed MX-1 tumor growth (P<0.05) by greater than 80% with 17% complete antitumor responses and up to three-fold increase in time to three tumor doublings over controls. Median survival in the P388-1 (P<0.001) model was increased by 9 days over controls [2]. The IV MTD of palifosfamide lysine in mice was 100 mg/kg per day for three consecutive days. Tumor growth inhibition was seen in both OS31 and OS33 xenografts and the RMS xenograft resulting in a significant difference in event-free survival between the control and the treated groups [1].Clinical trial PICASSO A Study of Palifosfamide Tris Plus Doxorubicin Versus Doxorubicin in Unresectable or Metastatic Soft-Tissue Sarcoma . Phase2

储存温度：避光,-20°C储存,充氩

运输条件：超低温冰袋运输

产品介绍：说明Palifosfamide是一种新的DNA烷化剂和异环磷酰胺的活性代谢物， 具有抗癌活性。

ALogP：-0.4

PubChem SID：488187209

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488187209

IUPAC Name：bis(2-chloroethylamino)phosphinic acid

INCHI：InChI=1S/C4H11Cl2N2O2P/c5-1-3-7-11(9,10)8-4-2-6/h1-4H2,(H3,7,8,9,10)

InChi Key：BKCJZNIZRWYHBN-UHFFFAOYSA-N

Canonical SMILES：C(CCl)NP(=O)(NCCCl)O

Isomeric SMILES：C(CCl)NP(=O)(NCCCl)O

PubChem CID：100427

溶解性：44 mg/mL(199.08 mM) in DMSO; 2 mg/ml (9.05 mM) in ethanol;13 mg/mL(58.82 mM) in water;

敏感性：对光线敏感

产品包装