产品名称

英文名称：HBTU

同义词

1-[Bis(dimethylamino)methylene]-1H-benzotriazolium 3-Oxide Hexafluorophosphate、1-[双(二甲氨基)亚甲基]-1H-苯并三唑鎓3-氧化物六氟磷酸盐

产品性质

CAS编号：94790-37-1

分子式：C11H16F6N5OP

分子量：379.24

Beilstein号：7328329

EC号：423-020-5

MDL号：MFCD00075445

PubChem编号：2733084

别名：1-[双(二甲氨基)亚甲基]-1H-苯并三唑鎓3-氧化物六氟磷酸盐

英文别名：1-[Bis(dimethylamino)methylene]-1H-benzotriazolium 3-Oxide Hexafluorophosphate

规格或纯度：99%

英文名称：HBTU

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

产品介绍：应用HBTU是用于多肽合成的多肽偶联剂。它也被用于标准Fmoc固相多肽合成（SPPS）方案。最近研究显示，这种偶联试剂的结晶或溶液结构是胍的 N-氧化物形式，,而不是脲化合物； 用于多肽合成的偶联试剂；优点是极低的外消旋化，简单的反应条件，非常短的反应时间和高产率。 ApplicationHBTU is a peptide coupling agent used for peptide synthesis. It is also used in the standard Fmoc solid-phase peptide synthesis (SPPS) protocol.Recent studies have shown that the crystal or solution structure of this coupling reagent is in the N-oxide form of guanidine, rather than urea compounds; Coupling reagents for peptide synthesis; The advantages are extremely low racemization, simple reaction conditions, very short reaction time, and high yield.

IUPAC Name：[benzotriazol-1-yloxy(dimethylamino)methylidene]-dimethylazanium;hexafluorophosphate

INCHI：InChI=1S/C11H16N5O.F6P/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;1-7(2,3,4,5)6/h5-8H,1-4H3;/q+1;-1

InChi Key：UQYZFNUUOSSNKT-UHFFFAOYSA-N

Canonical SMILES：CN(C)C(=[N+](C)C)ON1C2=CC=CC=C2N=N1.F[P-](F)(F)(F)(F)F

Isomeric SMILES：CN(C)C(=[N+](C)C)ON1C2=CC=CC=C2N=N1.F[P-](F)(F)(F)(F)F

WGK Germany：3

PubChem CID：2733084

Reaxy-Rn：4650356

溶解性：Soluble in acetonitrile.

密度：1.5095

敏感性：易吸潮,对光敏感

熔点：202-212°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH228 Flammable solid

预防措施声明：P261,P305+P351+P338,P280,P370+P378,P210,P302+P352,P321,P405,P501,P240,P264,P271,P241,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

个人防护装备：dust mask type N95 (US),Eyeshields,Gloves

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