产品名称

英文名称：Iniparib (BSI-201)

同义词

4-Iodo-3-nitrobenzamide、Iniparib、160003-66-7、BSI-201、Iniparib (BSI-201)、BSI 201、Benzamide, 4-iodo-3-nitro-、SAR240550、IND-71677、BSI201、NSC-746045、2ZWI7KHK8F、MFCD11110639、Iniparib [USAN]、NIBA、INO2BA、Iniparib [USANINN]、UNII-2ZWI7KHK8F、C7H5IN2O3、4tki、33E、SAR

产品性质

CAS编号：160003-66-7

分子式：C7H5IN2O3

分子量：292.03

PubChem编号：9796068

英文别名：4-Iodo-3-nitrobenzamide|Iniparib|160003-66-7|BSI-201|Iniparib (BSI-201)|BSI 201|Benzamide, 4-iodo-3-nitro-|SAR240550|IND-71677|BSI201|NSC-746045|2ZWI7KHK8F|MFCD11110639|Iniparib [USAN]|NIBA|INO2BA|Iniparib [USANINN]|UNII-2ZWI7KHK8F|C7H5IN2O3|4tki|33E|SAR

规格或纯度：≥98%

英文名称：Iniparib (BSI-201)

生化机理：BSI-201(Iniparib) is a potent PARP1 inhibitor with strong anti-neoplastic effect.Non-selective modifier of cysteine-containing proteins.\xa0Able to\xa0inhibit ionizing radiation-induced single-strand breaks (SSBs) repair in vitro . No ability to inhibit PARP enzymatic activity.

储存温度：室温

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Iniparib (BSI-201)是一种PARP1抑制剂，对三阴性乳腺癌(TNBC)有效。Iniparib (BSI-201) is an antineoplastic originally thoμght to be a poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor. Recent studies indicate Iniparib is not a PARP-1 inhibitor, and its mechanism of action is currently unknown.Iniparib (BSI-201) is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC).Iniparib (BSI-201) is an antineoplastic originally thought to be a poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor. Recent studies indicate Iniparib is not a PARP-1 inhibitor, and its mechanism of action is currently unknown.

ALogP：1.3

IUPAC Name：4-iodo-3-nitrobenzamide

INCHI：InChI=1S/C7H5IN2O3/c8-5-2-1-4(7(9)11)3-6(5)10(12)13/h1-3H,(H2,9,11)

InChi Key：MDOJTZQKHMAPBK-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=C(C=C1C(=O)N)[N+](=O)[O-])I

Isomeric SMILES：C1=CC(=C(C=C1C(=O)N)[N+](=O)[O-])I

WGK Germany：3

PubChem CID：9796068

CAS Registry No.：160003-66-7

RCSB PDB Ligand：33E

溶解性：DMSO ≥56mg/mL Water <1.2mg/mL Ethanol ≥35mg/mL

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH302 Harmful if swallowed

预防措施声明：P305+P351+P338,P280,P501,P264,P270,P330,P264+P265,P301+P317,P337+P317

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