产品名称

英文名称：UK-5099

同义词

56396-35-1、UK-5099、UK 5099、2-Cyano-3-(1-phenylindol-3-yl)acrylate、2-Cpiya、(E)-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic acid、(E)-2-cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid、UK5099、2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid、2-Cyano-3-(1-phenyl、2-氰基-3-(1-苯基-1H-吲哚-3-基)-2-丙烯酸

产品性质

CAS编号：56396-35-1

分子式：C18H12N2O2

分子量：288.3

MDL号：MFCD19443867

PubChem编号：6438504

别名：2-氰基-3-(1-苯基-1H-吲哚-3-基)-2-丙烯酸

英文别名：56396-35-1|UK-5099|UK 5099|2-Cyano-3-(1-phenylindol-3-yl)acrylate|2-Cpiya|(E)-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic acid|(E)-2-cyano-3-(1-phenyl-1H-indol-3-yl)acrylic acid|UK5099|2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid|2-Cyano-3-(1-phenyl

规格或纯度：98%

英文名称：UK-5099

生化机理：质膜单羧酸盐转运蛋白（MCT）和线粒体丙酮酸载体（MPC）的抑制剂。UK-5099 induces lactate generation.

法律信息：Sold for only research purposes

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：UK-5099产品介绍UK-5099 (PF-1005023) 是线粒体丙酮酸转运蛋白 (MPC) 的有效抑制剂， 抑制丙酮酸依赖性O2消耗的 IC50 值为50 nM。applicationUK-5099 has been usedas a mitochondrial pyruvate blocker to reduce pyruvate transportation into mitochondria in Roswell park memorial institute (RPMI) 1640 medium for prostatic cancer cell line culturein dimethyl sulfoxide (DMSO) stock, to study the effect of inhibiting pyruvate transport into mitochondria on pro-inflammatory responses in lipopolysaccharide activated macrophagesin topical treatment in order to study its effect on hair cycle induction in experimental mice.Product descriptionUK-5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier (MPC). UK-5099 (PF-1005023) inhibits pyruvate-dependent O2 consumption with an IC50 of 50 nM.

PubChem SID：488195788

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488195788

IUPAC Name：(E)-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic acid

INCHI：InChI=1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+

InChi Key：BIZNHCWFGNKBBZ-JLHYYAGUSA-N

Canonical SMILES：C1=CC=C(C=C1)N2C=C(C3=CC=CC=C32)C=C(C#N)C(=O)O

Isomeric SMILES：C1=CC=C(C=C1)N2C=C(C3=CC=CC=C32)/C=C(\C#N)/C(=O)O

WGK Germany：3

PubChem CID：6438504

CAS Registry No.：56396-35-1

ChEMBL Ligand：CHEMBL4303684

溶解性：溶于DMSO, 最高浓度 (mg/mL) 28.83, 最高浓度(mM) 100

敏感性：对热敏感

产品包装