产品名称

英文名称：Dovitinib (TKI-258, CHIR-258)

同义词

CHIR-258、C75053、D77370、BDBM153731、GFKI-258、MFCD10565680、NCGC00249685-11、TK-258、AC-32059、B2693-091881、Dovitinib、Q27163255、SCHEMBL32934、1447274-99-8、4-AMINO-5-FLUORO-3-[ 5- (4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2(1H)-ONE、TKI 258、UNII-I35H55、多韦替尼

产品性质

CAS编号：405169-16-6

分子式：C21H21FN6O

分子量：392.43

PubChem编号：135398510

别名：多韦替尼

英文别名：CHIR-258|C75053|D77370|BDBM153731|GFKI-258|MFCD10565680|NCGC00249685-11|TK-258|AC-32059|B2693-091881|Dovitinib|Q27163255|SCHEMBL32934|1447274-99-8|4-AMINO-5-FLUORO-3-[ 5- (4-METHYLPIPERAZIN-1-YL)-1H-BENZIMIDAZOL-2-YL]QUINOLIN-2(1H)-ONE|TKI 258|UNII-I35H55

规格或纯度：≥99%

英文名称：Dovitinib (TKI-258, CHIR-258)

生化机理：Dovitinib, Free Base, is the non-salt form of dovitinib, lactate salt (sc-396753). Dovitinib is a multitargeted growth factor receptor kinase inhibitor to VEGFR, FGFR3, PDGFR and c-KIT.Potent, selective inhibitor of class III-V receptor tyrosine kinases (RTKs). Inhibits FLT3 (IC 50 = 1 nM), c-KIT (IC 50 = 2 nM), FGFR (IC 50 = 8 nM), VEGFR1/2/3 (IC 50 values are\xa010 nM, 13 nM and 8 nM respectively)。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Dovitinib (TKI-258, CHIR-258)是一种多靶点的RTK抑制剂，对III型(FLT3/c-Kit)作用最强，IC50为1 nM/2 nM，同时也作用于IV类(FGFR1/3)和V类(VEGFR1-4) RTKs，IC50为8-13 nM，但对InsR， EGFR， c-Met， EphA2， Tie2， IGF-1R和HER2作用较弱。The free base form of an FGFR inhibitorDovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2.The free base form of an FGFR inhibitor

IUPAC Name：4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one

INCHI：InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)

InChi Key：PIQCTGMSNWUMAF-UHFFFAOYSA-N

Canonical SMILES：CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N

Isomeric SMILES：CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N

PubChem CID：135398510

ChEMBL Ligand：CHEMBL522892

CAS Registry No.：405169-16-6

Reactome Reaction：R-HSA-2077420, R-HSA-9669893, R-HSA-9669898, R-HSA-1839039, R-HSA-2023462

Reactome Drug：R-ALL-1839035

溶解性：DMSO34 mg/mL,Insoluble in water and Ethanol

产品包装