产品名称

英文名称：Methylglyoxal

同义词

Glyoxal, methyl 、 Propanolone 、 acetylformaldehyde 、 2-Oxopropanal 、 pyruvaldehyde 、 pyruvic aldehyde 、 METHYL GLYOXAL 、 Acetylformyl 、 methylglyoxal 、 Pyroracemic aldehyde 、 Propanedione 、 2-Ketopropionaldehyde 、 2-Oxopropionaldehyde 、 Propanal, 2-oxo-、甲基乙二醛 、 甲基乙二醛 溶液 、 2-氧代丙醛

产品性质

CAS编号：78-98-8

分子式：C3H4O2

分子量：72.06

Beilstein号：906750

MDL号：MFCD00006960

PubChem编号：880

别名：甲基乙二醛 | 甲基乙二醛 溶液 | 2-氧代丙醛

英文别名：Glyoxal, methyl | Propanolone | acetylformaldehyde | 2-Oxopropanal | pyruvaldehyde | pyruvic aldehyde | METHYL GLYOXAL | Acetylformyl | methylglyoxal | Pyroracemic aldehyde | Propanedione | 2-Ketopropionaldehyde | 2-Oxopropionaldehyde | Propanal, 2-oxo-

规格或纯度：40%溶液

英文名称：Methylglyoxal

应用：用作医药、农药中间体及生化试剂

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

产品介绍：甲基乙二醛（MG）是一种葡萄糖代谢物，其与糖尿病患者的周围神经病和疼痛相关。它可上调感觉神经元中的细胞内钙并产生行为伤害感受。甲基乙二醛具有抗菌性。MG可作为蛋白-糖化剂和晚期糖基化终产物的前体。它会损害糖尿病伤口的愈合。甲基乙二醛溶液已用于评估乙二醛酶1 (GLO1)的酶活性；在体外作为制备白蛋白的晚期糖基化终末（AGE）形成剂；调节小鼠焦虑样行为；诱导大鼠腹膜纤维化；研究有机化学品和金属DNA加合物的色谱保留特性；用于小鼠足底内注射以研究甲基乙二醛（MG）-瞬时受体电位锚蛋白1（TRPA1）-腺苷酸环化酶1同种型（AC1）途径的外周和中心组成。Methylglyoxal (MG) is a glucose metabolite, which is linked to peripheral neuropathy and pain in diabetic patients. It enhances intracellular calcium in sensory neurons and produces behavioral nociception. Methylglyoxal has antibacterial property. MG functions as a protein-glycating agent and precursor of advanced glycation end products. It impairs diabetic wound healing.Methylglyoxal solution has been usedto assess glyoxalase 1 (GLO1) enzymatic activity；as an advanced glycation end (AGE) forming agent for the preparation of albumin in vitro；to regulate anxiety like behavior in mice；to induce peritoneal fibrosis in rats；to study the chromatographic retention characteristics of organic chemicals and metal DNA adducts；for intraplantar injection in mice to investigate peripheral and central components of methylglyoxal (MG)-transient receptor potential ankyrin 1 (TRPA1)-adenylyl cyclase 1 isoform (AC1) pathway.Pyruvic aldehyde is used in the synthesis and cytotoxicity evaluation of N-terminal analogues of tubulysin-U an antimitotic compound. Also used in the synthesis of imidazoles as potent calcitonin gene-related CGRP antagonists.

IUPAC Name：2-oxopropanal

INCHI：InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3

InChi Key：AIJULSRZWUXGPQ-UHFFFAOYSA-N

Canonical SMILES：CC(=O)C=O

Isomeric SMILES：CC(=O)C=O

WGK Germany：3

PubChem CID：880

UN Number：1993

Packing Group：I

溶解性：Soluble in DMSO, water.

密度：1.178

敏感性：对湿度和空气敏感

折光率：1.4209

沸点：72°C

熔点：25°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH341 Suspected of causing genetic defectsH302 Harmful if swallowedH318 Causes serious eye damageH317 May cause an allergic skin reactionH290 May be corrosive to metals

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P281,P271,P270,P304+P340,P403+P233,P272,P333+P313,P362+P364,P330,P234,P390,P406,P203,P264+P265,P301+P317,P305+P354+P338,P318,P317,P337+P317,P332+P317,P319

Class：3

个人防护装备：Eyeshields,Faceshields,full-face respirator (US),Gloves,multi-purpose combination respirator cartridge (US),type ABEK (EN14387) respirator filter

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