产品名称

英文名称：Voriconazole

同义词

VORICONAZOLE [EMA EPAR]、Voriconazole, Pharmaceutical Secondary Standard Certified Reference Material、AB00639948_08、CHEBI10023、Tox21_500150、V0116、Voriconazol、BDBM50333117、Delnav、HY-W337569、( inverted exclamation markA)-Voriconazole、(.ALPHA.R,.BETA.S)-A-(、伏立康唑

产品性质

CAS编号：137234-62-9

分子式：C16H14F3N5O

分子量：349.31

MDL号：MFCD00905717

PubChem编号：71616

别名：伏立康唑

英文别名：VORICONAZOLE [EMA EPAR]|Voriconazole, Pharmaceutical Secondary Standard Certified Reference Material|AB00639948_08|CHEBI10023|Tox21_500150|V0116|Voriconazol|BDBM50333117|Delnav|HY-W337569|( inverted exclamation markA)-Voriconazole|(.ALPHA.R,.BETA.S)-A-(

规格或纯度：≥98%

英文名称：Voriconazole

生化机理：Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.Potent and broad-spectrum anti-fungal agent. Inhibits CYP450-dependent 14-α sterol demethylase, to interfere with ergosterol biosynthesis and inhibit fungal growth. Active in vivo .

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Voriconazole (伏立康唑; UK-109496) 是第二代三唑类抗真菌化合物，可作用于严重的真菌感染。An antifungal CYP2C9 inhibitorVoriconazole is a new triazole derivative similar to fluconazole and itraconazole that acts by inhibiting fungal cytochrome P-450-dependent, 14-alpha-sterol demethylase-mediated synthesis of ergosterol.An antifungal CYP2C9 inhibitor

ALogP：1.5

IUPAC Name：(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol

INCHI：InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1

InChi Key：BCEHBSKCWLPMDN-MGPLVRAMSA-N

Canonical SMILES：CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O

Isomeric SMILES：C[C@@H](C1=NC=NC=C1F)[C@](CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O

WGK Germany：3

RTECS：UV9145000

PubChem CID：71616

Reaxy-Rn：7694998

溶解性：DMSO 2 mg/mL, clear

密度：1.4

比旋光度：-58.0 to -62.0 deg(C=1, MeOH)

沸点：~508.6° C at 760 mmHg

熔点：128-134°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH351 Suspected of causing cancerH373 Causes damage to organs through prolonged or repeated exposureH412 Harmful to aquatic life with long lasting effectsH400 Very toxic to aquatic lifeH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P321,P405,P501,P264,P260,P270,P391,P330,P203,P301+P316,P318,P319

Merck Index：10033

产品包装