产品名称

英文名称：Gliquidone

同义词

Gliquidone、33342-05-1、Glurenorm、Gliquidonum、ARDF 26、Beglynor、Gliquidone (INN)、ARDF-26、1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea、C7C2QDD75P、N-(Cyclohexylcarbamoyl)-4-(2-(7-methoxy-4,4-dimethyl-1,3-diox、糖肾平、格列喹酮

产品性质

CAS编号：33342-05-1

分子式：C27H33N3O6S

分子量：527.63

MDL号：MFCD00631870

PubChem编号：91610

别名：糖肾平|格列喹酮

英文别名：Gliquidone|33342-05-1|Glurenorm|Gliquidonum|ARDF 26|Beglynor|Gliquidone (INN)|ARDF-26|1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea|C7C2QDD75P|N-(Cyclohexylcarbamoyl)-4-(2-(7-methoxy-4,4-dimethyl-1,3-diox

规格或纯度：≥98%

英文名称：Gliquidone

生化机理：Gliquidone is an ATP-dependent K+ (KATP) channel blocker. Gliquidone is an anti-diabetic drμg in the sulfonylurea class. Gliquidone is used in the treatment of diabetes mellitus type 2. This block causes a depolarization which leads to activation of voltage-dependent Ca channels and Ca2+ influx, and eventually increases insulin release.Potent ATP-dependent K + channel blocker (IC 50 = 27 nM). Increases voltage-dependent Ca 2+ influx. Increases insulin release and shows antidiabetic effects in vivo. Orally active.

应用：An ATP-dependent K+ (KATP) channel blocker.

运输条件：常规运输

备注：卖完停产，不再备货.如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Gliquidone是一种ATP敏感的K+通道拮抗剂，IC50为27.2 nMAn ATP-dependent K+ (KATP) channel blocker.Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM.An ATP-dependent K+ (KATP) channel blocker.

IUPAC Name：1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea

INCHI：InChI=1S/C27H33N3O6S/c1-27(2)23-14-11-20(36-3)17-22(23)24(31)30(25(27)32)16-15-18-9-12-21(13-10-18)37(34,35)29-26(33)28-19-7-5-4-6-8-19/h9-14,17,19H,4-8,15-16H2,1-3H3,(H2,28,29,33)

InChi Key：LLJFMFZYVVLQKT-UHFFFAOYSA-N

Canonical SMILES：CC1(C2=C(C=C(C=C2)OC)C(=O)N(C1=O)CCC3=CC=C(C=C3)S(=O)(=O)NC(=O)NC4CCCCC4)C

Isomeric SMILES：CC1(C2=C(C=C(C=C2)OC)C(=O)N(C1=O)CCC3=CC=C(C=C3)S(=O)(=O)NC(=O)NC4CCCCC4)C

RTECS：DB1584250

PubChem CID：91610

Reaxy-Rn：1559726

溶解性：Soluble in DMSO (105 mg/ml at 25 °C), water (< 1 mg/ml at 25 °C), and ethanol (6 mg/ml at 25 °C).

熔点：179 °C

Merck Index：4443

产品包装