产品名称

英文名称：17-AAG

同义词

Tanespimycin、75747-14-7、17-AAG、17-(Allylamino)-17-demethoxygeldanamycin、17AAG、NSC-330507、17-(Allylamino)geldanamycin、KOS-953、17-Allylaminogeldanamycin、Cp 127374、NSC 330507、17-Demethoxy-17-allylamino geldanamycin、BMS-722782、Tanespimycin [USAN]、CHEBI64153、替拉替尼、坦螺旋霉素

产品性质

CAS编号：75747-14-7

分子式：C31H43N3O8

分子量：585.69

MDL号：MFCD04973892

PubChem编号：6505803

别名：替拉替尼|坦螺旋霉素

英文别名：Tanespimycin|75747-14-7|17-AAG|17-(Allylamino)-17-demethoxygeldanamycin|17AAG|NSC-330507|17-(Allylamino)geldanamycin|KOS-953|17-Allylaminogeldanamycin|Cp 127374|NSC 330507|17-Demethoxy-17-allylamino geldanamycin|BMS-722782|Tanespimycin [USAN]|CHEBI64153|

规格或纯度：98%

英文名称：17-AAG

生化机理：17-AAG is a less toxic and more stable analog of geldanamycin. It acts an Hsp90 inhibitor that displays a 100-fold higher affinity for Hsp90 derived from tumor cells compared to Hsp90 from normal cells. 17-AAG inhibits Akt1 (Akt) activation and expression in tumors and synergizes with a number of anti tumor agents such as taxol2, cisplatin3, and UCN-014. 17-AAG causes the inactivation, destabilization and eventual degradation of HIF-1α5. 17-AAG is an inhibitor of K-Ras and N-Ras.

储存温度：-20°C储存

运输条件：超低温冰袋运输

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产品介绍：17-AAG (Tanespimycin)是一种有效的HSP90抑制剂，IC50为5 nM，作用于从肿瘤细胞提取的HSP90比作用于从正常细胞提取的HSP90结合亲和力高100倍。A potent Hsp90 inhibitor for tumor cells17-AAG (Tanespimycin) is a potent HSP90 inhibitor with IC50 of 5 nM, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells.A potent Hsp90 inhibitor for tumor cells

IUPAC Name：[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-enylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate

INCHI：InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9-,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1

InChi Key：AYUNIORJHRXIBJ-TXHRRWQRSA-N

Canonical SMILES：CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC

Isomeric SMILES：C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)/C)OC)OC(=O)N)\C)C)O)OC

WGK Germany：3

PubChem CID：6505803

溶解性：Soluble in DMSO (≥20 mg/ml at 25 °C), methanol (10 mg/ml), chloroform (10 mg/ml yielding a clear purple solution), water (<1 mg/ml at 25 °C), and ethanol (≥5 mg/ml at 25 °C).

敏感性：对光敏感

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装