产品名称

英文名称：AC480 (BMS-599626)

同义词

BMS-599626、714971-09-2、AC480、AC-480、BMS 599626、(S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate、AC480 (BMS-599626)、BMS599626、CHEMBL1645462、BMS-599626 (AC480)、2252724U5N、Carbamic ac、[4-[[1-(3-氟苄基)-1H-吲唑-5-基]氨基]-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基]氨基甲酸(S)-吗啉-3-基甲酯

产品性质

CAS编号：714971-09-2

分子式：C27H27FN8O3

分子量：530.55

MDL号：MFCD10565678

PubChem编号：10437018

别名：[4-[[1-(3-氟苄基)-1H-吲唑-5-基]氨基]-5-甲基吡咯并[2,1-f][1,2,4]三嗪-6-基]氨基甲酸(S)-吗啉-3-基甲酯

英文别名：BMS-599626|714971-09-2|AC480|AC-480|BMS 599626|(S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate|AC480 (BMS-599626)|BMS599626|CHEMBL1645462|BMS-599626 (AC480)|2252724U5N|Carbamic ac

规格或纯度：≥98%

英文名称：AC480 (BMS-599626)

生化机理：BMS-599626 is a potent inhbitor of human epidermal growth factor receptors 1 and 2 (HER1 and HER2, IC50 = 20 and 30 nM, respectively). BMS599626 inhibits proliferation of several HER-expressing cancer cell lines, including HER2-overexpressing breast cancer lines, but does not affect the proliferation rate of HER-negative cancer cell lines

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：AC480 (BMS-599626)是 HER1和HER2选择性高效抑制剂，IC50分别为20 nM和30 nM，比针对VEGFR2，c-Kit，Lck，MET的抑制性强100倍以上。AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc.

ALogP：2.8

IUPAC Name：[(3S)-morpholin-3-yl]methyl N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate

INCHI：InChI=1S/C27H27FN8O3/c1-17-23(34-27(37)39-15-22-14-38-8-7-29-22)13-36-25(17)26(30-16-32-36)33-21-5-6-24-19(10-21)11-31-35(24)12-18-3-2-4-20(28)9-18/h2-6,9-11,13,16,22,29H,7-8,12,14-15H2,1H3,(H,34,37)(H,30,32,33)/t22-/m0/s1

InChi Key：LUJZZYWHBDHDQX-QFIPXVFZSA-N

Canonical SMILES：CC1=C2C(=NC=NN2C=C1NC(=O)OCC3COCCN3)NC4=CC5=C(C=C4)N(N=C5)CC6=CC(=CC=C6)F

Isomeric SMILES：CC1=C2C(=NC=NN2C=C1NC(=O)OC[C@@H]3COCCN3)NC4=CC5=C(C=C4)N(N=C5)CC6=CC(=CC=C6)F

PubChem CID：10437018

CAS Registry No.：714971-09-2

ChEMBL Ligand：CHEMBL1645462

溶解性：DMSO 113 mg/mL Water <1 mg/mL Ethanol 20 mg/mL

敏感性：对热敏感

产品包装