产品名称

英文名称：SCH772984

同义词

3-Pyrrolidinecarboxamide, 1-[2-oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-(3-phenyl-1H-indazol-5-yl)-, (3R)-；(3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide；SCH 77

产品性质

CAS编号：942183-80-4

分子式：C33H33N9O2

分子量：587.67

PubChem编号：24866313

英文别名：3-Pyrrolidinecarboxamide, 1-[2-oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-(3-phenyl-1H-indazol-5-yl)-, (3R)-；(3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide；SCH 77

规格或纯度：≥98%

英文名称：SCH772984

生化机理：SCH772984 is a novel and selective inhibitor of ERK1/2 which displays behaviors of both type I and type II kinase inhibitors. SCH772984 has nanomolar cellular potency on tumor cells with mutations in BRAF, NRAS, or KRAS and induces tumor regressions in xenograft models at tolerated doses. SCH772984 effectively inhibited MAPK signaling and cell proliferation in BRAF or MEK inhibitor resistant models as well as in tumor cells resistant to concurrent treatment with BRAF and MEK inhibitors

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍SCH772984是一种新型特异性的ERK1/2抑制剂，无细胞试验中IC50分别为4 nM和1 nM, 对含有RAS或BRAF突变的癌细胞具有强大的功效。SCH772984，通过基于亲和力的质谱高通量平台而鉴定到，是一种新型有效的和ATP竞争性的ERK1和ERK2抑制剂，IC50值分别为4 nmol/L和1 nmol/L。尽管SCH772984具有I型和II型激酶抑制剂的行为，但在300个激酶的实验中，SCH772984只对7种激酶具有高选择性，包括CLK2、FLT4、GSG2、MAP4K4、MAPK1、MINK1、PRKD1和TTK，在1 μmol/L浓度时具有超过50％的抑制。研究结果表明，SCH772984在纳摩尔浓度时有效抑制含BRAF、NRAS和KRAS突变的肿瘤细胞的生长。

IUPAC Name：(3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide

INCHI：InChI=1S/C33H33N9O2/c43-30(42-18-16-41(17-19-42)27-5-2-24(3-6-27)32-35-11-1-12-36-32)22-40-15-10-25(21-40)33(44)37-26-4-7-29-28(20-26)31(39-38-29)23-8-13-34-14-9-23/h1-9,11-14,20,25H,10,15-19,21-22H2,(H,37,44)(H,38,39)/t25-/m1/s1

InChi Key：HDAJDNHIBCDLQF-RUZDIDTESA-N

Canonical SMILES：C1CN(CC1C(=O)NC2=CC3=C(C=C2)NN=C3C4=CC=NC=C4)CC(=O)N5CCN(CC5)C6=CC=C(C=C6)C7=NC=CC=N7

Isomeric SMILES：C1CN(C[C@@H]1C(=O)NC2=CC3=C(C=C2)NN=C3C4=CC=NC=C4)CC(=O)N5CCN(CC5)C6=CC=C(C=C6)C7=NC=CC=N7

PubChem CID：24866313

CAS Registry No.：942183-80-4

RCSB PDB Ligand：38Z, F3Z

Reactome Reaction：R-HSA-9657603

Reactome Drug：R-ALL-9657543

溶解性：DMSO mg/mL Water mg/mL Ethanol mg/mL

产品包装