产品名称

英文名称：Motesanib Diphosphate (AMG-706)

同义词

Motesanib diphosphate、857876-30-3、AMG-706、Motesanib (Diphosphate)、Motesanib Diphosphate (AMG-706)、Motesanib diphosphate [USAN]、Motesanib phosphate、AMG 706 (Diphosphate)、AMG 706;、T6Q3060U91、Motesanib phosphate (JAN)、Motesanib diphosphate (USAN)、N-(3,3-dime、二磷酸莫替沙尼、AMG 706

产品性质

CAS编号：857876-30-3

分子式：C22H23N5O·2H3PO4

分子量：569.44

PubChem编号：16097729

别名：二磷酸莫替沙尼|AMG 706

英文别名：Motesanib diphosphate|857876-30-3|AMG-706|Motesanib (Diphosphate)|Motesanib Diphosphate (AMG-706)|Motesanib diphosphate [USAN]|Motesanib phosphate|AMG 706 (Diphosphate)|AMG 706;|T6Q3060U91|Motesanib phosphate (JAN)|Motesanib diphosphate (USAN)|N-(3,3-dime

规格或纯度：≥98%

英文名称：Motesanib Diphosphate (AMG-706)

生化机理：Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3, PDGFR, c-Kit and Ret with IC50 of 2 nM, 3 nM, 6 nM, 84 nM, 8 nM and 59 nM, respectively.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：Motesanib Diphosphate (AMG-706)是一种有效的ATP竞争性的VEGFR1/2/3抑制剂，IC50分别为2 nM/3 nM/6 nM；对Kit具有相似的抑制活性，对VEGFR选择性比PDGFR和Ret高10倍。An ATP-competitive inhibitor.Motesanib Diphosphate (AMG-706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 2 nM/3 nM/6 nM, respectively; similar activity against Kit, ~10-fold more selective for VEGFR than PDGFR and Ret.An ATP-competitive inhibitor.

IUPAC Name：N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide;phosphoric acid

INCHI：InChI=1S/C22H23N5O.2H3O4P/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15;2*1-5(2,3)4/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28);2*(H3,1,2,3,4)

InChi Key：ONDPWWDPQDCQNJ-UHFFFAOYSA-N

Canonical SMILES：CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C.OP(=O)(O)O.OP(=O)(O)O

Isomeric SMILES：CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C.OP(=O)(O)O.OP(=O)(O)O

PubChem CID：16097729

溶解性：Soluble in DMSO (100 mg/ml at 25 °C), water (100 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).

产品包装