产品名称

英文名称：Crizotinib

同义词

Crizotinib、877399-52-5、Xalkori、(R)-crizotinib、PF-02341066、PF-2341066、PF 2341066、(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine、Crizotinib (PF-02341066)、crizotinibum、3-[(1R)-1-(2,6-Dichloro-3-fluoropheny、克里唑替尼、3-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺、克唑替尼、(R)-3-[1-(2,6-二氯-3-氟 - 苯基)-乙氧基]-5-(1-哌啶-4-基-1H-吡唑-4-基)-吡啶-2-基胺、克唑替尼、PF02341066、PF 2341066

产品性质

CAS编号：877399-52-5

分子式：C21H22Cl2FN5O

分子量：450.34

PubChem编号：11626560

别名：克里唑替尼|3-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺|克唑替尼|(R)-3-[1-(2,6-二氯-3-氟 - 苯基)-乙氧基]-5-(1-哌啶-4-基-1H-吡唑-4-基)-吡啶-2-基胺|克唑替尼|PF02341066|PF 2341066

英文别名：Crizotinib|877399-52-5|Xalkori|(R)-crizotinib|PF-02341066|PF-2341066|PF 2341066|(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine|Crizotinib (PF-02341066)|crizotinibum|3-[(1R)-1-(2,6-Dichloro-3-fluoropheny

规格或纯度：≥99%

英文名称：Crizotinib

生化机理：克唑替尼（PF-02341066）是受体酪氨酸激酶。 Crizotinib (PF-02341066) is an ATP-competitive inhibitor of the receptor tyrosine kinases (RTKs) c-Met (hepatocyte growth factor receptor) and anaplastic lymphoma kinase (ALK). Crizotinib is a highly specific inhibitor of c-Met and ALK among > 120 different RTKs surveyed. Crizotinib was approved for treatment of a subtype of nonsmall-cell lung cancer (NSCLC) with ALK fusion mutations.c-MET和间变性淋巴瘤激酶（ALK）受体酪氨酸激酶的强效，xa0ATP竞争性xa0抑制剂（细胞IC 50值分别为8.0和20 nM）。对c-MET和ALK具有针对> 120种不同激酶的选择性。在下列药物中显示抗肿瘤功效

储存温度：2-8°C储存

运输条件：冰袋运输

备注：10mg、50mg卖完停产，不再备货；如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：PF-2341066 shows inhibition of Met phosphorylation in mIMCD3 mouse of MDCK canine epithelial cells with an IC50 of 5 nM and 20 nM, respectively, as well as NCI-H69 and HOP92 cells, with an IC50 of 13 nM and 16 nM, respectively. PF-2341066 shows a near-equivalent IC50 of 24 nM against the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncogenic fusion varient of the ALK RTK expressed by the KARPAS299 human anaplastic large-cell lymphoma (ALCL) cell line. PF-2341066 supresses human GTL-16 gastric carcinoma cell growth with an IC50 of 9.7 nM. PF-2341066 induces apoptosis in GTL-16 cells with an IC5050 of 30 nM.A Met inhibitor effective against various cell linesCrizotinib has been used· to investigate its effects on hepatocyte growth factor receptor (c-Met) expression, proliferation and apoptosis· to block neurotrophic tyrosine kinase receptor type 1 (NTRK1) activity in epithelial cells· to restore sensitivity to erlotinibPF-2341066 shows inhibition of Met phosphorylation in mIMCD3 mouse of MDCK canine epithelial cells with an IC50 of 5 nM and 20 nM, respectively, as well as NCI-H69 and HOP92 cells, with an IC50 of 13 nM and 16 nM, respectively. PF-2341066 shows a near-equivalent IC50 of 24 nM against the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncogenic fusion varient of the ALK RTK expressed by the KARPAS299 human anaplastic large-cell lymphoma (ALCL) cell line. PF-2341066 supresses human GTL-16 gastric carcinoma cell growth with an IC50 of 9.7 nM. PF-2341066 induces apoptosis in GTL-16 cells with an IC5050 of 30 nM.A Met inhibitor effective against various cell linesCrizotinib has been used· to investigate its effects on hepatocyte growth factor receptor (c-Met) expression, proliferation and apoptosis· to block neurotrophic tyrosine kinase receptor type 1 (NTRK1) activity in epithelial cells· to restore sensitivity to erlotinib

ALogP：3.7

PubChem SID：488197629

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488197629

IUPAC Name：3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

INCHI：InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1

InChi Key：KTEIFNKAUNYNJU-GFCCVEGCSA-N

Canonical SMILES：CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

Isomeric SMILES：C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

PubChem CID：11626560

UN Number：3077

Packing Group：III

溶解性：Soluble in DMSO (25 mg/mL warming), ethanol (25 mg/mL warming), methanol, and chloroform. Insoluble in water.

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH341 Suspected of causing genetic defectsH318 Causes serious eye damageH317 May cause an allergic skin reactionH400 Very toxic to aquatic life

预防措施声明：P261,P305+P351+P338,P273,P280,P302+P352,P321,P405,P501,P281,P272,P333+P313,P362+P364,P391,P203,P264+P265,P305+P354+P338,P318,P317,P337+P317

Class：9

RIDADR：UN 3077 9 / PGIII

产品包装