产品名称

英文名称：Fedratinib (SAR302503, TG101348)

同义词

Fedratinib、936091-26-8、Tg-101348、TG101348、SAR302503、SAR-302503、N-(tert-butyl)-3-((5-methyl-2-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide、SAR 302503、Inrebic、TG 101348、Fedratinib (SAR302503, TG101348)、UNII-6L1XP550I6

产品性质

CAS编号：936091-26-8

分子式：C27H36N6O3S

分子量：524.68

PubChem编号：16722836

英文别名：Fedratinib|936091-26-8|Tg-101348|TG101348|SAR302503|SAR-302503|N-(tert-butyl)-3-((5-methyl-2-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide|SAR 302503|Inrebic|TG 101348|Fedratinib (SAR302503, TG101348)|UNII-6L1XP550I6|

规格或纯度：≥98%

英文名称：Fedratinib (SAR302503, TG101348)

生化机理：TG-101348 is a potent, highly selective JAK2 inhibitor.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：TG-101348 (SAR302503)是JAK2选择性抑制剂，IC50为3 nM，作用于JAK2比作用于JAK1和JAK3选择性高35和334倍，同时还能抑制BRD4，IC50为340 nM。A selective inhibitor of JAK2 tyrosine kinaseTG-101348 (SAR302503) is a selective inhibitor of JAK2 with IC50 of 3 nM, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3, TG-101348 also inhibit BRD4 with IC50 of 340 nM.A selective inhibitor of JAK2 tyrosine kinase

ALogP：4.8

IUPAC Name：N-tert-butyl-3-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzenesulfonamide

INCHI：InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)

InChi Key：JOOXLOJCABQBSG-UHFFFAOYSA-N

Canonical SMILES：CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4

Isomeric SMILES：CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4

PubChem CID：16722836

CAS Registry No.：936091-26-8

Wikipedia：TG101348

DiscoveRx TREEspot：TG-101348|

ChEMBL Ligand：CHEMBL1287853

RCSB PDB Ligand：2TA

Reactome Reaction：R-HSA-9680408

Reactome Drug：R-ALL-9680406

DrugCentral Ligand：5347

溶解性：DMSO 105 mg/mL Water <1 mg/mL Ethanol 21 mg/mL

象形图：

信号词：Warning

危险声明：H302 Harmful if swallowedH361d Suspected of damaging the unborn child

预防措施声明：P280,P405,P501,P264,P270,P330,P203,P301+P317,P318

产品包装