产品名称

英文名称：IC-87114

同义词

IC-87114、371242-69-2、IC87114、2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one、IC 87114、2-[(6-aminopurin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one、9HC746B1KF、CHEMBL1213082、CHEBI90686、D-030、2-[(6-Amino-9h-Purin-9-Yl)m

产品性质

CAS编号：371242-69-2

分子式：C22H19N7O

分子量：397.43

PubChem编号：9908783

英文别名：IC-87114|371242-69-2|IC87114|2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one|IC 87114|2-[(6-aminopurin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one|9HC746B1KF|CHEMBL1213082|CHEBI90686|D-030|2-[(6-Amino-9h-Purin-9-Yl)m

规格或纯度：≥98%

英文名称：IC-87114

生化机理：IC-87114 selectively inhibits PI3Kδ, and is not sensitive to PI3Kα, β, or γ. In human neutrophils, IC-87114 (5 μM) potently inhibits N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated phosphatidylinositol triphosphate (PIP3) biosynthesis and chemotaxis. In human acute myeloid leukemia (AML) blast cells, such as bone marrow mononuclear cells (BMMCs), IC-87114 (10 μM) inhibits both constitutive and Flt-3-stimulated Akt phosphorylation and cell proliferation. It is also found that IC-87114 (5 μM–30 &mui;M) inhibits SCF- or IL-3-stimulated BMMC responses, which are not observed in PI3Kδ mutant (p110δD910A) cells.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：IC-87114是第一个PI3K同工酶选择型抑制剂，对p110δ抑制性最高，IC50为130nM，而对p110α，p110β和p110γ的IC50分别为200 μM，16 μM和61 μM。A PI3K inhibitor with action against fMLP-PIP3IC-87114 is a selective PI3Kδ inhibitor with IC50 of 0.5 μM in a cell-free assay, 58-fold more selective for PI3Kδ than PI3Kγ, and over 100-fold more selective than PI3Kα/βA PI3K inhibitor with action against fMLP-PIP3

IUPAC Name：2-[(6-aminopurin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)quinazolin-4-one

INCHI：InChI=1S/C22H19N7O/c1-13-6-3-4-9-16(13)29-17(27-15-8-5-7-14(2)18(15)22(29)30)10-28-12-26-19-20(23)24-11-25-21(19)28/h3-9,11-12H,10H2,1-2H3,(H2,23,24,25)

InChi Key：GNWHRHGTIBRNSM-UHFFFAOYSA-N

Canonical SMILES：CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C=NC5=C(N=CN=C54)N

Isomeric SMILES：CC1=C2C(=CC=C1)N=C(N(C2=O)C3=CC=CC=C3C)CN4C=NC5=C(N=CN=C54)N

PubChem CID：9908783

ChEMBL Ligand：CHEMBL1213082

CAS Registry No.：371242-69-2

BindingDB Ligand：50323726

RCSB PDB Ligand：IC8

溶解性：DMSO ≥4.8mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

产品包装