产品名称

英文名称：PCI-24781 (Abexinostat)

同义词

ABEXINOSTAT、783355-60-2、PCI-24781、PCI 24781、CRA-024781、CRA 024781、CRA-02478、3-((dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)benzofuran-2-carboxamide、PCI24781、CRA 24781、Abexinostat [USAN]、Abexinostat (PCI-24781)、PCI-24781 (Abexinostat)、S7

产品性质

CAS编号：783355-60-2

分子式：C21H23N3O5

分子量：397.42

PubChem编号：11749858

英文别名：ABEXINOSTAT|783355-60-2|PCI-24781|PCI 24781|CRA-024781|CRA 024781|CRA-02478|3-((dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)benzofuran-2-carboxamide|PCI24781|CRA 24781|Abexinostat [USAN]|Abexinostat (PCI-24781)|PCI-24781 (Abexinostat)|S7

规格或纯度：≥97%

英文名称：PCI-24781 (Abexinostat)

生化机理：PCI-24781 is a broad spectrum hydroxamic acid-based inhibitor of HDAC that shows antitumor activity in vitro. PCI-24781 inhibited pure recombinant HDAC1 with a Ki of 0.007 Mmol/L, as well as HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 in the nanomolar range. Antitumor activity of PCI-24781 was observed in all 10 tumor cell lines tested, with GI50% values ranging from 0.15 to 3.09 μmol/L.Broad spectrum phenyl hydroamic acid inhibitor of HDAC (histone deacetylase). Nanomolar potency in cell-free assays (HDAC1 K i = 7nM; HDAC2 K i = 19 nM; HDAC3 K i = 8.2 nM; HDAC6 K i = 17nM; HDAC8 IC 50 = 280 nM; HDAC10 IC 50 = 24 nM). Inhibits several is

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：PCI-24781 (Abexinostat)是一种新型的pan-HDAC抑制剂，靶向作用于HDAC1，Ki为7 nM，对HDACs 2， 3， 6，和10有适中的抑制性，但比作用于HDAC8选择性强40倍。An HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 inhibitor.PCI-24781 (Abexinostat) is a novel pan-HDAC inhibitor mostly targeting HDAC1 with Ki of 7 nM, modest potent to HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8.An HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 inhibitor.

ALogP：2.2

IUPAC Name：3-[(dimethylamino)methyl]-N-[2-[4-(hydroxycarbamoyl)phenoxy]ethyl]-1-benzofuran-2-carboxamide

INCHI：InChI=1S/C21H23N3O5/c1-24(2)13-17-16-5-3-4-6-18(16)29-19(17)21(26)22-11-12-28-15-9-7-14(8-10-15)20(25)23-27/h3-10,27H,11-13H2,1-2H3,(H,22,26)(H,23,25)

InChi Key：MAUCONCHVWBMHK-UHFFFAOYSA-N

Canonical SMILES：CN(C)CC1=C(OC2=CC=CC=C21)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO

Isomeric SMILES：CN(C)CC1=C(OC2=CC=CC=C21)C(=O)NCCOC3=CC=C(C=C3)C(=O)NO

PubChem CID：11749858

ChEMBL Ligand：CHEMBL2103863

CAS Registry No.：783355-60-2

溶解性：DMSO ≥78mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL

象形图：

信号词：Danger

危险声明：H311 Toxic in contact with skinH373 Causes damage to organs through prolonged or repeated exposureH411 Toxic to aquatic life with long lasting effectsH314 Causes severe skin burns and eye damageH302 Harmful if swallowedH318 Causes serious eye damageH361 Suspected of damaging fertility or the unborn child

预防措施声明：P273,P280,P302+P352,P321,P405,P501,P264,P260,P270,P301+P330+P331,P304+P340,P363,P391,P330,P361+P364,P203,P264+P265,P301+P317,P305+P354+P338,P318,P317,P302+P361+P354,P316,P319

产品包装