产品名称

英文名称：Volasertib (BI 6727)

同义词

Volasertib、755038-65-4、BI 6727、Volasertib (BI 6727)、BI-6727、BI6727 (Volasertib)、Volasertib [USAN]、Volasertib(BI6727)、BI6727、6EM57086EA、Volasertib (USAN)、N-(Trans-4-(4-(cyclopropylMethyl)piperazin-1-yl)cyclohexyl)-4-(((R)-7-ethyl-8-isopropyl-5-Methyl-6-oxo

产品性质

CAS编号：755038-65-4

分子式：C34H50N8O3

分子量：618.83

PubChem编号：10461508

英文别名：Volasertib|755038-65-4|BI 6727|Volasertib (BI 6727)|BI-6727|BI6727 (Volasertib)|Volasertib [USAN]|Volasertib(BI6727)|BI6727|6EM57086EA|Volasertib (USAN)|N-(Trans-4-(4-(cyclopropylMethyl)piperazin-1-yl)cyclohexyl)-4-(((R)-7-ethyl-8-isopropyl-5-Methyl-6-oxo

规格或纯度：≥97%

英文名称：Volasertib (BI 6727)

生化机理：BI6727 is an ATP-competitive Plk1/2/3 inhibitor from the dihydropteridinone family with IC50 values of 5 nM and 56 nM, respectively. BI6727 inhibits the proliferation of multiple cell lines derived from various cancer tissues, including HCT116, NCI-H460, BRO, GRANTA-519, HL-60, THP-1, and Raji cells with EC50 of 23 nM, 21 nM, 11 nM, 15 nM, 32 nM, 36 nM, and 37 nM, respectively. BI6727 displays potent inhibitory activity against neuroblastoma tumor-initiating cells (NB TIC) with EC50 of 21 nM.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、25mg卖完停产，不再备货

产品介绍：Volasertib(BI6727)是高活性PLK1抑制剂，IC50为0.87 nM，比对Plk2和Plk3的抑制性高6倍和65倍。Volasertib(BI6727) is a highly potent PLK1 inhibitor with an IC50 of 0.87 nM; shows 6- and 65-fold greater selectivity against Plk2 and Plk3.

IUPAC Name：N-[4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-4-[[(7R)-7-ethyl-5-methyl-6-oxo-8-propan-2-yl-7H-pteridin-2-yl]amino]-3-methoxybenzamide

INCHI：InChI=1S/C34H50N8O3/c1-6-28-33(44)39(4)29-20-35-34(38-31(29)42(28)22(2)3)37-27-14-9-24(19-30(27)45-5)32(43)36-25-10-12-26(13-11-25)41-17-15-40(16-18-41)21-23-7-8-23/h9,14,19-20,22-23,25-26,28H,6-8,10-13,15-18,21H2,1-5H3,(H,36,43)(H,35,37,38)/t25?,26?,28-/m1/s1

InChi Key：SXNJFOWDRLKDSF-XKHVUIRMSA-N

Canonical SMILES：CCC1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C

Isomeric SMILES：CC[C@@H]1C(=O)N(C2=CN=C(N=C2N1C(C)C)NC3=C(C=C(C=C3)C(=O)NC4CCC(CC4)N5CCN(CC5)CC6CC6)OC)C

PubChem CID：10461508

CAS Registry No.：755038-65-4

ChEMBL Ligand：CHEMBL1233528

Wikipedia：Volasertib

RCSB PDB Ligand：IBI

溶解性：DMSO 50 mg/mL Water <1 mg/mL Ethanol 124 mg/mL

密度：1.3

折光率：1.63

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH373 Causes damage to organs through prolonged or repeated exposureH300 Fatal if swallowedH361 Suspected of damaging fertility or the unborn child

预防措施声明：P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P270,P362+P364,P330,P203,P264+P265,P301+P316,P318,P337+P317,P332+P317,P319

产品包装