产品名称

英文名称：SU1498

同义词

su1498、168835-82-3、(E)-2-CYANO-3-(4-HYDROXY-3,5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE、SU-1498、SU 1498、Tyrphostin SU 1498、CHEMBL261508、CHEBI87158、AG 1498、(2E)-2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide、AG、(E)-2-氰基-3-(4-羟基-3,5-二异丙基苯基)-N-(3-苯丙基)丙烯酰胺、酪氨酸磷酸化抑制剂SU 1498

产品性质

CAS编号：168835-82-3

分子式：C25H30N2O2

分子量：390.52

MDL号：MFCD03453026

PubChem编号：5941539

别名：(E)-2-氰基-3-(4-羟基-3,5-二异丙基苯基)-N-(3-苯丙基)丙烯酰胺|酪氨酸磷酸化抑制剂SU 1498

英文别名：su1498|168835-82-3|(E)-2-CYANO-3-(4-HYDROXY-3,5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE|SU-1498|SU 1498|Tyrphostin SU 1498|CHEMBL261508|CHEBI87158|AG 1498|(2E)-2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-2-propenamide|AG

规格或纯度：98% (HPLC)

英文名称：SU1498

生化机理：SU1498 is a potent and selective inhibitor of the VEGFR2 receptor kinase, Flk-1 with an IC50 value of 700 nM. SU1498 is a very weak inhibitor of PDGFR-kinase, EGFR-kinase and HER-2 kinase with IC50 values > 50 μM. SU1498 has been used to study the role of VEGFR2 (Flk-1) in a variety of biological activities including angiogenesis, tumor growth inhibition, and stem cell proliferation.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：不稳定重新制作解决方案并立即使用。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：产品介绍SU1498 (AG 1498) 是选择性的 VEGFR2 抑制剂；抑制 Flk-1 的 IC50 值为 700 nM。

IUPAC Name：(E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-N-(3-phenylpropyl)prop-2-enamide

INCHI：InChI=1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+

InChi Key：JANPYFTYAGTSIN-FYJGNVAPSA-N

Canonical SMILES：CC(C)C1=CC(=CC(=C1O)C(C)C)C=C(C#N)C(=O)NCCCC2=CC=CC=C2

Isomeric SMILES：CC(C)C1=CC(=CC(=C1O)C(C)C)/C=C(\C#N)/C(=O)NCCCC2=CC=CC=C2

PubChem CID：5941539

敏感性：对热敏感

熔点：126 °C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

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