产品名称

英文名称：Emricasan

同义词

Emricasan、254750-02-2、IDN-6556、PF-03491390、(S)-3-((S)-2-(2-(2-TERT-BUTYLPHENYLAMINO)-2-OXOACETAMIDO)PROPANAMIDO)-4-OXO-5-(2,3,5,6-TETRAFLUOROPHENOXY)PENTANOIC ACID、PF 03491390、(S)-3-((S)-2-(2-((2-(tert-Butyl)phenyl)amino)-2-oxoacetamido)propanamido)-4-oxo

产品性质

CAS编号：254750-02-2

分子式：C26H27F4N3O7

分子量：569.51

PubChem编号：12000240

英文别名：Emricasan|254750-02-2|IDN-6556|PF-03491390|(S)-3-((S)-2-(2-(2-TERT-BUTYLPHENYLAMINO)-2-OXOACETAMIDO)PROPANAMIDO)-4-OXO-5-(2,3,5,6-TETRAFLUOROPHENOXY)PENTANOIC ACID|PF 03491390|(S)-3-((S)-2-(2-((2-(tert-Butyl)phenyl)amino)-2-oxoacetamido)propanamido)-4-oxo

规格或纯度：≥98%

英文名称：Emricasan

生化机理：Emricasan is an antiapoptotic pan-caspase inhibitor. It has been in clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) with advanced fibrosis (scarring) and cirrhosis. Emricasan has also been shown to protect infected astrocytes from ZIKV-induced cell death. Emricasan, formerly known as IDN-6556, in combination with birinapan is used to treat acute myeloid leukemia (AML). This small molecule irreversible inhibitor is under clinical investigation to reduce hepatic injury and liver fibrosis.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Emricasan (IDN-6556, PF 03491390, PF-03491390)是有效的、不可逆的泛半胱天冬酶（pan-caspase）抑制剂。Emricasan 也是寨卡病毒感染的抑制剂。 Emricasan (PF 03491390) 是一种有效的 不可逆 pan-caspase 抑制剂。Emricasan 抑制 Zika 病毒 (ZIKV) 诱导的 caspase-3 活性增加并保护了人类皮层神经祖细胞。

ALogP：3.6

IUPAC Name：(3S)-3-[[(2S)-2-[[2-(2-tert-butylanilino)-2-oxoacetyl]amino]propanoyl]amino]-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid

INCHI：InChI=1S/C26H27F4N3O7/c1-12(31-24(38)25(39)32-16-8-6-5-7-13(16)26(2,3)4)23(37)33-17(10-19(35)36)18(34)11-40-22-20(29)14(27)9-15(28)21(22)30/h5-9,12,17H,10-11H2,1-4H3,(H,31,38)(H,32,39)(H,33,37)(H,35,36)/t12-,17-/m0/s1

InChi Key：SCVHJVCATBPIHN-SJCJKPOMSA-N

Canonical SMILES：CC(C(=O)NC(CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=CC=CC=C2C(C)(C)C

Isomeric SMILES：C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)COC1=C(C(=CC(=C1F)F)F)F)NC(=O)C(=O)NC2=CC=CC=C2C(C)(C)C

PubChem CID：12000240

CAS Registry No.：254750-02-2

ChEMBL Ligand：CHEMBL197672

溶解性：DMSO

产品包装