产品名称

英文名称：UK 383367

同义词

348622-88-8、UK 383367、UK-383367、(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide、CHEMBL226630、5-[(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazole-3-carboxamide、5-{(1R)-4-cyclohexyl-1-[2-(hydroxya

产品性质

CAS编号：348622-88-8

分子式：C15H24N4O4

分子量：324.38

MDL号：MFCD19690945

PubChem编号：9818682

英文别名：348622-88-8|UK 383367|UK-383367|(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide|CHEMBL226630|5-[(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazole-3-carboxamide|5-{(1R)-4-cyclohexyl-1-[2-(hydroxya

规格或纯度：98%

英文名称：UK 383367

生化机理：BMP-1（前胶原C蛋白酶； PCP）的有效和选择性抑制剂（IC50 = 44 nM）。对MMP 1、2、3、9和14的BMP-1选择性（对于列出的MMP，IC50值> 10,000 nM）。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Product DescribtionUK 383367 is a novel procollagen C-protein (PCP) inhibitor being investigated for the treatment of post-surgical dermal scarring, which potently inhibits the activity of PCP with the value of 50% inhibition concentration IC50 of 44 nM, as well as a selective inhibitor of matrix metalloproteinases (MMPs) with values of IC50 >60,000 nM for MMP-2 and >10,000 nM for MMP-1, MMP-3, MMP-9 and MMP-4. Although the mechanism is not clear yet, UK 383367 also exhibits weak inhibitory effects against phosphodiesterase-4 (PDE-4) enzyme, including PDE-4a, PDE-4b, PDE-4c and PDE-4d, with values of IC50 of 1.8 μM, 1.5 μM, 2.4 μM and 0.9 μM respectively.

IUPAC Name：5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide

INCHI：InChI=1S/C15H24N4O4/c16-13(21)14-17-15(23-19-14)11(9-12(20)18-22)8-4-7-10-5-2-1-3-6-10/h10-11,22H,1-9H2,(H2,16,21)(H,18,20)/t11-/m1/s1

InChi Key：ARJCBSRIPGJMAD-LLVKDONJSA-N

Canonical SMILES：C1CCC(CC1)CCCC(CC(=O)NO)C2=NC(=NO2)C(=O)N

Isomeric SMILES：C1CCC(CC1)CCC[C@H](CC(=O)NO)C2=NC(=NO2)C(=O)N

WGK Germany：3

PubChem CID：9818682

溶解性：溶于DMSO, 最高浓度 (mg/mL) 32.44, 最高浓度(mM) 100

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowed

预防措施声明：P301+P310

产品包装