产品名称

英文名称：LRRK2-IN-1

同义词

LRRK2-IN-1、1234480-84-2、LRRK2IN1、LRRK2-IN1、2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one、2-((2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-di

产品性质

CAS编号：1234480-84-2

分子式：C31H38N8O3

分子量：570.7

PubChem编号：46843906

英文别名：LRRK2-IN-1|1234480-84-2|LRRK2IN1|LRRK2-IN1|2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one|2-((2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5,11-di

规格或纯度：98%

英文名称：LRRK2-IN-1

生化机理：LRRK2-IN-1 is a cell-permeable, ATP competitive, potent, and selective LRRK2 inhibitor. (IC50 of 13 nM, 6 nM, and 2.45 μM for wild type, G2019S mutant, and drμg resistant A2016T mutant LRRK2, respectively, in an in vitro ATP-site competititon binding assay). LRRK2-IN-1 is useful in treatment of Parkinson's disease.Potent and selective inhibitor of the Parkinson’s disease kinase LRRK2. Benzodiazepine based derivative. Inhibits both G2019S mutant and wild-type LRRK2 kinase activity (IC 50 values are 6 and 13 nM respectively).

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：有关更多信息，请参考SDS。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：product descriptionLRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2 (G2019S) and LRRK2 (WT), respectively.

IUPAC Name：2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one

INCHI：InChI=1S/C31H38N8O3/c1-35-15-17-38(18-16-35)22-11-13-39(14-12-22)29(40)21-9-10-24(27(19-21)42-4)33-31-32-20-26-28(34-31)36(2)25-8-6-5-7-23(25)30(41)37(26)3/h5-10,19-20,22H,11-18H2,1-4H3,(H,32,33,34)

InChi Key：IWMCPJZTADUIFX-UHFFFAOYSA-N

Canonical SMILES：CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC

Isomeric SMILES：CN1CCN(CC1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)NC4=NC=C5C(=N4)N(C6=CC=CC=C6C(=O)N5C)C)OC

PubChem CID：46843906

ChEMBL Ligand：CHEMBL2012582

CAS Registry No.：1234480-84-2

BindingDB Ligand：50379529

RCSB PDB Ligand：4K4

溶解性：DMSO

产品包装