产品名称

英文名称：Hesperadin

同义词

hesperadin、422513-13-1、hesperadine、UNII-PTR491OS14、CHEBI70726、TCMDC-135395、CHEMBL514409、PTR491OS14、(Z)-N-(2-oxo-3-(phenyl((4-(piperidin-1-ylmethyl)phenyl)amino)methylene)indolin-5-yl)ethanesulfonamide、N-[(3Z)-2-oxo-3-[phenyl-[4-(piperidin-1-ylmethyl)anil、N-(2,3-二氢-2-氧代-3-((3Z)-苯基((4-(1-哌啶基甲基)苯基)氨基)亚甲基)-1H-吲哚-5-基)乙磺酰胺

产品性质

CAS编号：422513-13-1

分子式：C29H32N4O3S

分子量：516.67

PubChem编号：135421442

别名：N-(2,3-二氢-2-氧代-3-((3Z)-苯基((4-(1-哌啶基甲基)苯基)氨基)亚甲基)-1H-吲哚-5-基)乙磺酰胺|

英文别名：hesperadin|422513-13-1|hesperadine|UNII-PTR491OS14|CHEBI70726|TCMDC-135395|CHEMBL514409|PTR491OS14|(Z)-N-(2-oxo-3-(phenyl((4-(piperidin-1-ylmethyl)phenyl)amino)methylene)indolin-5-yl)ethanesulfonamide|N-[(3Z)-2-oxo-3-[phenyl-[4-(piperidin-1-ylmethyl)anil

规格或纯度：≥98%

英文名称：Hesperadin

生化机理：esperadin prevents the phosphorylation of recombinant trypanosome histone H3 by the T. brucei Aurora kinase-1 (TbAUK1) from pathogenic Trypanosoma brucei with IC50 of 40 nM in vitro kinase assays. Hesperadin significantly inhibits cell growth of cultured infectious bloodstream forms (BF) with IC50 of 48 nM, and only weakly inhibits cell growth of insect stage procyclic forms (PF) with IC50 of 550 nM. Hesperadin inhibits the ability of immunoprecipitated Aurora B to phosphorylate histone H3 with IC50 of 250 nM and markedly reduces the activity of other kinases (AMPK, Lck, MKK1, MAPKAP-K1, CHK1, and PHK) at a concentration of 1 μM.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Hesperadin是ATP竞争性Aurora B抑制剂，IC50为250 nM。Hesperadin potently inhibits Aurora B with IC50 of 250 nM in a cell-free assay. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo.

IUPAC Name：N-[2-hydroxy-3-[C-phenyl-N-[4-(piperidin-1-ylmethyl)phenyl]carbonimidoyl]-1H-indol-5-yl]ethanesulfonamide

INCHI：InChI=1S/C29H32N4O3S/c1-2-37(35,36)32-24-15-16-26-25(19-24)27(29(34)31-26)28(22-9-5-3-6-10-22)30-23-13-11-21(12-14-23)20-33-17-7-4-8-18-33/h3,5-6,9-16,19,31-32,34H,2,4,7-8,17-18,20H2,1H3

InChi Key：HYHIYZMIFPJROG-UHFFFAOYSA-N

Canonical SMILES：CCS(=O)(=O)NC1=CC2=C(C=C1)NC(=C2C(=NC3=CC=C(C=C3)CN4CCCCC4)C5=CC=CC=C5)O

Isomeric SMILES：CCS(=O)(=O)NC1=CC2=C(C=C1)NC(=C2C(=NC3=CC=C(C=C3)CN4CCCCC4)C5=CC=CC=C5)O

PubChem CID：135421442

CAS Registry No.：422513-13-1

ChEMBL Ligand：CHEMBL514409

Wikipedia：Hesperadin

RCSB PDB Ligand：FE7, FE7

溶解性：DMSO 103 mg/mL Water <1 mg/mL Ethanol <1 mg/mL

密度：1.3

熔点：>226°C

产品包装