产品名称

英文名称：AR-C155858

同义词

AR-C155858、496791-37-8、AR C155858、(S)-6-((3,5-dimethyl-1H-pyrazol-4-yl)methyl)-5-(4-hydroxyisoxazolidine-2-carbonyl)-1-isobutyl-3-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione、AR-C 155858、6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-[(4S)-4-hydroxy-1,2-oxa

产品性质

CAS编号：496791-37-8

分子式：C21H27N5O5S

分子量：461.53

PubChem编号：10226546

英文别名：AR-C155858|496791-37-8|AR C155858|(S)-6-((3,5-dimethyl-1H-pyrazol-4-yl)methyl)-5-(4-hydroxyisoxazolidine-2-carbonyl)-1-isobutyl-3-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione|AR-C 155858|6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-[(4S)-4-hydroxy-1,2-oxa

规格或纯度：≥95%

英文名称：AR-C155858

生化机理：单羧酸盐转运蛋白（MCT）MCT1和MCT2的抑制剂（Ki值分别为2.3和<10 nM）。在MCT4上没有任何活动。在体外阻断Raji淋巴瘤细胞的增殖。抑制癌细胞中的糖酵解和谷胱甘肽合成。

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：product descriptionAR-C 155858 is an inhibitor of monocarboxylate transporter 1 (MCT1) and MCT2 (Kis = 2.3 and <10 nM, respectively, in Xenopus oocytes expressing the human receptors).It is selective for MCT1 and MCT2 over MCT4 (Ki = >10 μM). AR-C 155858 inhibits L-lactate uptake in and proliferation of murine 4T1 breast cancer cells (IC50s = 25 and 20.2 nM, respectively)

IUPAC Name：6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-[(4S)-4-hydroxy-1,2-oxazolidine-2-carbonyl]-3-methyl-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4-dione

INCHI：InChI=1S/C21H27N5O5S/c1-10(2)7-25-20-17(18(28)24(5)21(25)30)16(19(29)26-8-13(27)9-31-26)15(32-20)6-14-11(3)22-23-12(14)4/h10,13,27H,6-9H2,1-5H3,(H,22,23)/t13-/m0/s1

InChi Key：ISIVOJWVBJIOFM-ZDUSSCGKSA-N

Canonical SMILES：CC1=C(C(=NN1)C)CC2=C(C3=C(S2)N(C(=O)N(C3=O)C)CC(C)C)C(=O)N4CC(CO4)O

Isomeric SMILES：CC1=C(C(=NN1)C)CC2=C(C3=C(S2)N(C(=O)N(C3=O)C)CC(C)C)C(=O)N4C[C@@H](CO4)O

PubChem CID：10226546

溶解性：溶于DMSO, 最高浓度 (mg/mL) 46.15, 最高浓度(mM) 100；insoluble in H2O；≥57.8 mg/mL in EtOH

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P337+P317,P332+P317,P319

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