产品名称

英文名称：Sodium salicylate

同义词

Sodium salicylate、54-21-7、Sodium 2-hydroxybenzoate、Enterosalicyl、Kerasalicyl、Salsonin、Alysine、Clin、Enterosalil、Entrosalyl、Glutosalyl、Kerosal、Magsalyl、Nadisal、Salisod、Aroall、Idocyl novum、Neo-salicyl、Benzoic acid, 2-hydroxy-, monosodium salt、Natrum salicyli、2-羟基苯甲酸单钠盐、水杨酸 钠盐、钠 2-羟苯甲酸、2-羟基苯甲酸 钠盐

产品性质

CAS编号：54-21-7

分子式：C7H5NaO3

分子量：160.1

Beilstein号：3732792

EC号：200-198-0

MDL号：MFCD00002440

PubChem编号：16760658

别名：2-羟基苯甲酸单钠盐|水杨酸 钠盐|钠 2-羟苯甲酸|2-羟基苯甲酸 钠盐

英文别名：Sodium salicylate|54-21-7|Sodium 2-hydroxybenzoate|Enterosalicyl|Kerasalicyl|Salsonin|Alysine|Clin|Enterosalil|Entrosalyl|Glutosalyl|Kerosal|Magsalyl|Nadisal|Salisod|Aroall|Idocyl novum|Neo-salicyl|Benzoic acid, 2-hydroxy-, monosodium salt|Natrum salicyli

规格或纯度：AR,≥99.5% (NT)

英文名称：Sodium salicylate

生化机理：Sodium salicylate is a metabolite of acetylsalicylic acid, and functions by inhibiting NF κ B and reduces oxidative stress. The agent has the ability to protect against neurotoxicity induced by glutamate in rat studies. Along with aspirin , sodium salicylate is an anti-inflammatory compound that binds to and inhibits IKK β. Sodium salicylate has been shown to reduce ATP binding in vitro and in vivo. Sodium Salicylate is an inhibitor of c-Jun and Cox-2 and an activator of p38.

储存温度：避光

运输条件：常规运输

产品介绍：易溶于水（10.8，25℃）和甘油（15），能溶于95%乙醇（111），几乎不溶于醚、氯仿和苯。水溶液呈微酸性（pH5-6）。久露光线中变粉红色。无臭或微带特殊的臭气，味甜呀不适。 水杨酸钠是阿司匹林中的活性成分，阿司匹林是解热，消炎镇痛常用药物。大量服用水杨酸钠会引起暂时听力丧失和耳鸣。使用水杨酸钠长期治疗会长期降低耳蜗分泌，降低体内化合物活性电位幅度和体外神经退化。杏仁外侧核水杨酸钠处理后会改变音调和兴奋性，导致听觉皮层过度活动。水杨酸钠能够减弱细胞内-Finkel?Biskis?Jinkins鼠成骨肉瘤病毒（c-fos）表达和海马区域 δ-FosB蛋白质，影响空间记忆和学习。水杨酸钠影响大脑齿状回区域神经发生。有机合成原料；防腐剂；测胃液中游离酸的试剂；点滴分析二氧化铀。解热镇痛药和抗风湿药。水杨酸钠可用于 · 诱导大鼠耳鸣，高敏样行为以及和杏仁体直接融合，检测区域场电位。 · 通过脉冲前抑制行为（PPI），来诱导和确定耳鸣。通过Morris水迷宫测试确定它对对于学习和记忆的抑制作用，以及之后的大鼠基因表达研下丘背皮质的听觉反应究。 · 用来增强γ氨基酸丁酸(GABA)能抑制，增强下丘背皮质（ICd）的听觉反应，可以通过微离子电泳技术检测。Sodium salicylate is the active ingredient in aspirin, commonly used as antipyretic, anti-inflammatory and analgesic drug. Sodium salicylate when taken in large quantities causes temporary hearing loss and tinnitus. Prolonged treatment with sodium salicylate reduces output from cochlea permanently, reduces compound action potential amplitude in vivo and neural degeneration in vitro.Sodium salicylate treatment in lateral amygdala alters tonography and excitability, causing hyperactivity in auditory cortex. Sodium salicylate impairs the expression of cellular-Finkel?Biskis?Jinkins murine osteogenic sarcoma virus (c-fos) and δ-FosB proteins in hippocampus region and affects spatial memory and learning. Sodium salicylate affects neurogenesis in dentate gyrus region of the brain.An NF kappa B inhibitor and reducer of oxidative stress.

PubChem SID：488199435

IUPAC Name：sodium;2-hydroxybenzoate

INCHI：InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1

InChi Key：ABBQHOQBGMUPJH-UHFFFAOYSA-M

Canonical SMILES：C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]

Isomeric SMILES：C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]

WGK Germany：1

RTECS：VO5075000

PubChem CID：16760658

溶解性：Soluble in water, 1,4-dioxane, ethanol and glycerol.

敏感性：对光敏感

闪点(℃)：98.3 °C

沸点：213 °C

熔点：>300℃

象形图：

信号词：Warning

危险声明：H319 Causes serious eye irritationH302 Harmful if swallowedH361 Suspected of damaging fertility or the unborn child

预防措施声明：P305+P351+P338,P280,P405,P501,P264,P270,P330,P203,P264+P265,P301+P317,P318,P337+P317

个人防护装备：dust mask type N95 (US),Eyeshields,Gloves

产品包装