产品名称

英文名称：TAK-700 (Orteronel)

同义词

6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide、426219-18-3、426219-32-1、TAK-700、TAK-700 (Orteronel)、TAK700、426219-23-0、Orteronel (racemic)、Orteronel (racemate)、TAK 700 racemate、6-(7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol

产品性质

CAS编号：426219-18-3

分子式：C18H17N3O2

分子量：307.35

PubChem编号：9883029

英文别名：6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide|426219-18-3|426219-32-1|TAK-700|TAK-700 (Orteronel)|TAK700|426219-23-0|Orteronel (racemic)|Orteronel (racemate)|TAK 700 racemate|6-(7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol

规格或纯度：98%

英文名称：TAK-700 (Orteronel)

生化机理：TAK-700 is an oral, selective, non-steroidal androgen synthesis inhibitor of the 17,20 lyase, which is a key enzyme in the production of steroidal hormones. In preclinical studies, TAK-700 has been shown to bind to and inhibit the enzyme 17,20 lygase in both the testes and adrenal glands. TAK-700 is currently under clinical Phase III studies.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：产品介绍TAK-700 (Orteronel) 是一种有效的，高度选择性的，人17，20-lyase抑制剂，IC50为38 nM，比作用于其他CYPs(例如11-羟化酶和CYP3A4)选择性高1000倍以上。TAK-700 (Orteronel) 是一种雄性激素 androgen 生物合成抑制剂。

IUPAC Name：6-(7-hydroxy-5,6-dihydropyrrolo[1,2-c]imidazol-7-yl)-N-methylnaphthalene-2-carboxamide

INCHI：InChI=1S/C18H17N3O2/c1-19-17(22)14-3-2-13-9-15(5-4-12(13)8-14)18(23)6-7-21-11-20-10-16(18)21/h2-5,8-11,23H,6-7H2,1H3,(H,19,22)

InChi Key：OZPFIJIOIVJZMN-UHFFFAOYSA-N

Canonical SMILES：CNC(=O)C1=CC2=C(C=C1)C=C(C=C2)C3(CCN4C3=CN=C4)O

Isomeric SMILES：CNC(=O)C1=CC2=C(C=C1)C=C(C=C2)C3(CCN4C3=CN=C4)O

PubChem CID：9883029

溶解性：DMSO 57 mg/mL (185.5 mM) Ethanol 8 mg/mL (26.02 mM) Water <1 mg/mL

象形图：

信号词：Danger

危险声明：H372 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P264,P260,P270,P203,P318,P319

产品包装