产品名称

英文名称：LY2090314

同义词

LY2090314、603288-22-8、LY-2090314、Kinome_3681、LY 2090314、3-(9-Fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione、CHEMBL362558、822M3GYM67、UNII-822M3GYM67、SCHEMBL633455

产品性质

CAS编号：603288-22-8

分子式：C28H25FN6O3

分子量：512.53

PubChem编号：10029385

英文别名：LY2090314|603288-22-8|LY-2090314|Kinome_3681|LY 2090314|3-(9-Fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione|CHEMBL362558|822M3GYM67|UNII-822M3GYM67|SCHEMBL633455|

规格或纯度：≥98%

英文名称：LY2090314

生化机理：LY2090314 is a potent and selective ATP-competitive inhibitor of Glycogen synthase kinase-3 (GSK-3) currently in clinical trials for cancer therapy. LY2090314 has IC50 values of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β, respectively.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：LY2090314是高活性GSK-3抑制剂，对GSK-3α和GSK-3β的IC50分别为1.5 nM和0.9 nM。LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens.

ALogP：2.5

IUPAC Name：3-[6-fluoro-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione

INCHI：InChI=1S/C28H25FN6O3/c29-18-12-17-15-34(28(38)32-7-3-1-4-8-32)11-10-33-16-20(19(13-18)25(17)33)23-24(27(37)31-26(23)36)21-14-30-22-6-2-5-9-35(21)22/h2,5-6,9,12-14,16H,1,3-4,7-8,10-11,15H2,(H,31,36,37)

InChi Key：HRJWTAWVFDCTGO-UHFFFAOYSA-N

Canonical SMILES：C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7

Isomeric SMILES：C1CCN(CC1)C(=O)N2CCN3C=C(C4=CC(=CC(=C43)C2)F)C5=C(C(=O)NC5=O)C6=CN=C7N6C=CC=C7

关联CAS：603288-22-8

PubChem CID：10029385

MeSH Entry Terms：3-(9-fluoro-2-(piperidin-1-ylcarbonyl)-1,2,3,4-tetrahydro(1,4)diazepino(6,7,1-hi)indol-7-yl)-4-imidazo(1,2-a)pyridin-3-yl-1H-pyrrole-2,5-dione;LY2090314

溶解性：DMSO mg/mL Water mg/mL Ethanol mg/mL

产品包装