产品名称

英文名称：NVP-LCQ195

同义词

NVP-LCQ195、902156-99-4、4-[(2,6-dichlorobenzoyl)amino]-N-(1-methylsulfonylpiperidin-4-yl)-1H-pyrazole-5-carboxamide、LCQ-195、SCHEMBL2029686、SCHEMBL17252164、DTXSID90470112、CCUXEBOOTMDSAM-UHFFFAOYSA-N、CLB15699、AT9311、AKOS037645025、AT-9311、CS-0840、NCGC00379060

产品性质

CAS编号：902156-99-4

分子式：C17H19Cl2N5O4S

分子量：460.33

PubChem编号：11655534

英文别名：NVP-LCQ195|902156-99-4|4-[(2,6-dichlorobenzoyl)amino]-N-(1-methylsulfonylpiperidin-4-yl)-1H-pyrazole-5-carboxamide|LCQ-195|SCHEMBL2029686|SCHEMBL17252164|DTXSID90470112|CCUXEBOOTMDSAM-UHFFFAOYSA-N|CLB15699|AT9311|AKOS037645025|AT-9311|CS-0840|NCGC00379060

规格或纯度：≥98%

英文名称：NVP-LCQ195

生化机理：NVP-LCQ195 (AT9311; LCQ195) is a small molecule heterocyclic compound which inhibits CDK1, CDK2 and CDK5, as well as CDK3 and CDK9. Cell cycle regulators, such as cyclin-dependent kinases (CDKs), are appealing targets for multiple myeloma (MM) therapy given the increased proliferative rates of tumour cells in advanced versus early stages of MM. NVP-LCQ195 induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-μmol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu.

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：卖完停产，不再备货

产品介绍：NVP-LCQ195 (AT9311; LCQ195)是CDK杂环类抑制剂，对CDK1，CDK2，CDK3和CDK5的IC50为1-42 nM。NVP-LCQ195 (AT9311; LCQ195) is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5 with IC50 of 1-42 nM.

IUPAC Name：4-[(2,6-dichlorobenzoyl)amino]-N-(1-methylsulfonylpiperidin-4-yl)-1H-pyrazole-5-carboxamide

INCHI：InChI=1S/C17H19Cl2N5O4S/c1-29(27,28)24-7-5-10(6-8-24)21-17(26)15-13(9-20-23-15)22-16(25)14-11(18)3-2-4-12(14)19/h2-4,9-10H,5-8H2,1H3,(H,20,23)(H,21,26)(H,22,25)

InChi Key：CCUXEBOOTMDSAM-UHFFFAOYSA-N

Canonical SMILES：CS(=O)(=O)N1CCC(CC1)NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl

Isomeric SMILES：CS(=O)(=O)N1CCC(CC1)NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl

PubChem CID：11655534

溶解性：DMSO

产品包装