产品名称

英文名称：Nicorandil

同义词

NICORANDIL、65141-46-0、Ikorel、2-Nicotinamidoethyl nitrate、Sigmart、SG-75、Dancor、Nicorandilum、Adancor、2-(pyridine-3-carbonylamino)ethyl nitrate、SG 75、2-(nicotinamido)ethyl nitrate、N-(2-Hydroxyethyl)nicotinamide nitrate、N-(2-Hydroxyethyl)nicotinamide nitrate、尼可地尔、烟浪丁、硝烟酯、2-(吡啶-3-羰基氨基)乙基硝酸酯, 2-烟酰胺基硝酸乙酯, N-2-硝氧乙基-3-吡啶键酰胺,N-[2-(硝氧基)乙基]吡啶-3-甲酰胺

产品性质

CAS编号：65141-46-0

分子式：C8H9N3O4

分子量：211.17

MDL号：MFCD00186520

PubChem编号：47528

别名：尼可地尔|烟浪丁|硝烟酯|2-(吡啶-3-羰基氨基)乙基硝酸酯, 2-烟酰胺基硝酸乙酯, N-2-硝氧乙基-3-吡啶键酰胺,N-[2-(硝氧基)乙基]吡啶-3-甲酰胺

英文别名：NICORANDIL|65141-46-0|Ikorel|2-Nicotinamidoethyl nitrate|Sigmart|SG-75|Dancor|Nicorandilum|Adancor|2-(pyridine-3-carbonylamino)ethyl nitrate|SG 75|2-(nicotinamido)ethyl nitrate|N-(2-Hydroxyethyl)nicotinamide nitrate|N-(2-Hydroxyethyl)nicotinamide nitrate

规格或纯度：≥98%(HPLC)

英文名称：Nicorandil

生化机理：Nicorandil is a small molecule KATP (Kir6) channel opener, producing relaxation of coronary vascular smooth muscle. Specific binding of Nicorandil to the C-terminus of the SUR2B K(ATP) channel generates K+ flux and hyperpolarization of the surface membrane, producing consequent closure of voltage-dependent ion channels and reduction of intracellular free Ca2+. Nicorandil stimulates guanylate cyclase and increases cyclic GMP levels in correlation with the activation of K(ATP) channels. Nicorandil is also described to suppress mitochondrial permeability transition triggered by oxidative stress resulting from ischemia-reperfusion, preventing mitochondrial calcium uptake/overload and oxidative damage. Nicorandil has also been shown to serve as a nitric oxide donor.ATP-sensitive K + channel activator (EC 50 values are 10 and 500 μM for SUR2A and SUR2B containing subtypes respectively). Shows vasodilatory effects in vivo. Orally active.

应用：A small molecule KATP (Kir6) channel opener and NO donor

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：SG-75,Nicorandil has been used as an activator of potassium (K+) channel and inhibitor of voltage-gated calcium channel to study its effects on action potentials in long QT syndrome 2 (LQTS2) human induced pluripotent stem cell (hiPSCs)-derived cardiomyocytes.SG-75,Nicorandil has been used as an activator of potassium (K+) channel and inhibitor of voltage-gated calcium channel to study its effects on action potentials in long QT syndrome 2 (LQTS2) human induced pluripotent stem cell (hiPSCs)-derived cardiomyocytes.

IUPAC Name：2-(pyridine-3-carbonylamino)ethyl nitrate

INCHI：InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)

InChi Key：LBHIOVVIQHSOQN-UHFFFAOYSA-N

Canonical SMILES：C1=CC(=CN=C1)C(=O)NCCO[N+](=O)[O-]

Isomeric SMILES：C1=CC(=CN=C1)C(=O)NCCO[N+](=O)[O-]

WGK Germany：3

RTECS：US4667600

PubChem CID：47528

Reaxy-Rn：481451

ChEBI：CHEBI31905

Wikipedia：Nicorandil

ChEMBL Ligand：CHEMBL284906

CAS Registry No.：65141-46-0

PEP：nicorandil

DrugCentral Ligand：1919

溶解性：Soluble in water (4 mg/ml), DMSO (>25 mg/ml), ethanol, ether, and methanol.

敏感性：对湿度敏感

熔点：90 °C

象形图：

信号词：Danger

危险声明：H302 Harmful if swallowedH318 Causes serious eye damage

预防措施声明：P280,P501,P264,P270,P330,P264+P265,P301+P317,P305+P354+P338,P317

Merck Index：6521

个人防护装备：dust mask type N95 (US)， Eyeshields， Gloves

产品包装