产品名称

英文名称：Betulin

同义词

2,2,2-Trichloro-1,1-bis(4-chlorophenyl)ethanol、2-Amino-2-ethylpropanediol、NCGC00168803-02、NSC 4644、Trochol、AI3-62999、CP BETULIN、Lup-20(30)-ene-3.beta.,28-diol、Q419726、Betuline、Betulinol (obsol.)、Diphesatin、ACon1_000091、AKOS005267212、NCGC00168803-04、Betuli、白桦脂醇

产品性质

CAS编号：473-98-3

分子式：C30H50O2

分子量：442.72

Beilstein号：6(3)5234

EC号：207-475-5

MDL号：MFCD00016802

PubChem编号：72326

别名：白桦脂醇

英文别名：2,2,2-Trichloro-1,1-bis(4-chlorophenyl)ethanol|2-Amino-2-ethylpropanediol|NCGC00168803-02|NSC 4644|Trochol|AI3-62999|CP BETULIN|Lup-20(30)-ene-3.beta.,28-diol|Q419726|Betuline|Betulinol (obsol.)|Diphesatin|ACon1_000091|AKOS005267212|NCGC00168803-04|Betuli

规格或纯度：98%

英文名称：Betulin

生化机理：Betulin is a triterpene with a pentacyclic ring structure and hydroxyl groups in positions C3 and C28. Studies indicate that Betulin can effect intracellular signaling in ethanol-induced liver cells via inhibiting ROS, TNFα and TNFβ. In human cancer cells Betulin can induce mitochondrial cytochrome C release in human cancer cells, which results in apoptosis. Alternate studies on mice show that Betulin binds to melanocortin receptors and antagonizes the release of cAMP generation in mouse melanoma cells. Furthermore, Betulin has protective effects against cadmium induced apoptosis in human hepatoma cell lines. This occurs by inhibiting the activation of ROS, blocking Bid activation and suppressing the mitochondrial pathway.

储存温度：2-8°C储存

运输条件：冰袋运输

产品介绍：桦木醇是一种具有羽扇豆核的三萜类化合物，存在于桦树的树皮中。在酸剂存在下发生重排形成同种桦木醇。桦木醇可用于桦木酸的制备，桦木酸具有抗 HIV、抗疟和抗炎活性。A triterpene with a pentacyclic ring structure.It can be used in the preparation of betulinic acid，which shows anti-HIV, antimalarial and anti-inflammatory activities.

IUPAC Name：(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysen-9-ol

INCHI：InChI=1S/C30H50O2/c1-19(2)20-10-15-30(18-31)17-16-28(6)21(25(20)30)8-9-23-27(5)13-12-24(32)26(3,4)22(27)11-14-29(23,28)7/h20-25,31-32H,1,8-18H2,2-7H3/t20-,21+,22-,23+,24-,25+,27-,28+,29+,30+/m0/s1

InChi Key：FVWJYYTZTCVBKE-ROUWMTJPSA-N

Canonical SMILES：CC(=C)C1CCC2(C1C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)CO

Isomeric SMILES：CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]3CC[C@@H]4[C@]5(CC[C@@H](C([C@@H]5CC[C@]4([C@@]3(CC2)C)C)(C)C)O)C)CO

WGK Germany：3

RTECS：OK5755000

PubChem CID：72326

Reaxy-Rn：2064515

比旋光度：19° (C=2,Pyridine)

熔点：256-257°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH302 Harmful if swallowedH312 Harmful in contact with skinH332 Harmful if inhaledH371 May cause damage to organs

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P260,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P317,P317,P337+P317,P308+P316,P332+P317,P319

Merck Index：1189

产品包装