产品名称

英文名称：Capecitabine

同义词

CAPECITABINE、154361-50-9、Xeloda、Capiibine、Capecitibine、Captabin、Capecytabine、Caxeta、Xabine、Capecitabine Sun、Capecitabine Teva、Capecitabine Medac、Capecitabine Accord、5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine、Ro 09-1978、capecitabina、capecitabinum、Ca、5'-脱氧-5-氟-N-[(戊氧基)羰基]胞苷

产品性质

CAS编号：154361-50-9

分子式：C15H22FN3O6

分子量：359.35

MDL号：MFCD00930626

PubChem编号：60953

别名：5'-脱氧-5-氟-N-[(戊氧基)羰基]胞苷

英文别名：CAPECITABINE|154361-50-9|Xeloda|Capiibine|Capecitibine|Captabin|Capecytabine|Caxeta|Xabine|Capecitabine Sun|Capecitabine Teva|Capecitabine Medac|Capecitabine Accord|5'-deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine|Ro 09-1978|capecitabina|capecitabinum|Ca

规格或纯度：≥99%

英文名称：Capecitabine

生化机理：Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrμg, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. The activation of capecitabine follows a pathway with three enzymatic steps and two intermediary metabolites, 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouridine (5'-DFUR), to form 5-fluorouracil. From Wikipedia.Selective, novel oral fluoropyrimidine carbamate. Prodrug of 5-Fluorouracil . Anticancer agent. Active in vitro and in vivo .

应用：An antiproliferative 5-fluorouracil releasing compound

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Capecitabine是一种治疗肿瘤选择性的氟嘧啶氨基甲酸酯，具有较高的瘤内5-FU水平，且毒性比5-FU低。An antiproliferative 5-fluorouracil releasing compoundCapecitabine is a tumor-selective fluoropyrimidine carbamate which achieves higher intratumoral 5-FU level with lower toxicity than 5-FU.An antiproliferative 5-fluorouracil releasing compound

ALogP：0.6

PubChem SID：488183411

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488183411

IUPAC Name：pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate

INCHI：InChI=1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1

InChi Key：GAGWJHPBXLXJQN-UORFTKCHSA-N

Canonical SMILES：CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2C(C(C(O2)C)O)O

Isomeric SMILES：CCCCCOC(=O)NC1=NC(=O)N(C=C1F)[C@H]2[C@@H]([C@@H]([C@H](O2)C)O)O

WGK Germany：3

关联CAS：154361-50-9

PubChem CID：60953

MeSH Entry Terms：capecitabine;N(4)-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine;Xeloda

DrugBank Ligand：DB01101

CAS Registry No.：154361-50-9

ChEMBL Ligand：CHEMBL1773

Wikipedia：Capecitabine

ChEBI：CHEBI31348

DrugCentral Ligand：480

溶解性：Soluble in water (26 mg/ml), ethanol (207 mg/ml), methanol (> 40%), DMF (~14 mg/ml), and DMSO (72 mg/ml at 25 °C).

敏感性：对热敏感

比旋光度：98° (C=1,MeOH)

熔点：123 °C(dec.)

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH341 Suspected of causing genetic defectsH360 May damage fertility or the unborn childH350 May cause cancer

预防措施声明：P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P281,P362+P364,P203,P264+P265,P318,P337+P317,P332+P317

Merck Index：1754

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