产品名称

英文名称：Indirubin-3′-oxime

同义词

INDIRUBIN-3'-MONOXIME、indirubin-3'-oxime、160807-49-8、Indirubin-3-monoxime、indirubin-3-oxime、Indirubin-3monoxime、667463-82-3、3-[3-(Hydroxyamino)-1H-indol-2-yl]indol-2-one、Indirubin 3'-monoxime、CHEBI43645、indirubin-3'-monooxime、(2Z,3E)-3-(Hydroxyimino)-[2,

产品性质

CAS编号：160807-49-8

分子式：C16H11N3O2

分子量：277.28

MDL号：MFCD02683594

PubChem编号：3707

英文别名：INDIRUBIN-3'-MONOXIME|indirubin-3'-oxime|160807-49-8|Indirubin-3-monoxime|indirubin-3-oxime|Indirubin-3monoxime|667463-82-3|3-[3-(Hydroxyamino)-1H-indol-2-yl]indol-2-one|Indirubin 3'-monoxime|CHEBI43645|indirubin-3'-monooxime|(2Z,3E)-3-(Hydroxyimino)-[2,

规格或纯度：≥98%(HPLC)

英文名称：Indirubin-3′-oxime

生化机理：Indirubin-3′-oxime is a cyclin-dependent kinase inhibitor which functions by competing with ATP for binding to the catalytic subunit; exhibits antiproliferative activity leading to G2/M arrest in many cell lines and G1/S arrest in Jurkat cells.Potent GSK3β inhibitor (IC 50 = 22 nM). CDK inhibitor (IC 50 values are 0.1 (Cdk5/p35), 0.18 (Cdk1/cyclin B), 0.25 (Cdk2/cyclin E), 0.5 (Cdk2/cyclin A) and 3.3 μM (Cdk4/cyclin D1)). Shows reversible antiproliferative effects via G 2 /M cell cycle arrest.

运输条件：常规运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Indirubin-3'-monoxime is a potent inhibitor of GSK-3β (IC50=22 nM)1. Indirubin-3'-monoxime also inhibits CDK1 (p34cdc2; IC50=180 nM) and CDK5 (IC50=100 nM)1. Indirubin-3'-monoxime reversibly arrests asynchronous HBL-100 cells at G22. This compound induces apoptosis in the mammary carcinoma cell line MCF-7 (10 μM). Indirubin-3'-monoxime is an inhibitor of Cdk2, cyclin A, cyclin B, cyclin E and p35.A potent inhibitor of GSK-3β, Cdk1, and Cdk5Indirubin-3'-monoxime is a potent inhibitor of GSK-3β (IC50=22 nM)1. Indirubin-3'-monoxime also inhibits CDK1 (p34cdc2; IC50=180 nM) and CDK5 (IC50=100 nM)1. Indirubin-3'-monoxime reversibly arrests asynchronous HBL-100 cells at G22. This compound induces apoptosis in the mammary carcinoma cell line MCF-7 (10 μM). Indirubin-3'-monoxime is an inhibitor of Cdk2, cyclin A, cyclin B, cyclin E and p35.A potent inhibitor of GSK-3β, Cdk1, and Cdk5

IUPAC Name：3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol

INCHI：InChI=1S/C16H11N3O2/c20-16-13(9-5-1-3-7-11(9)18-16)15-14(19-21)10-6-2-4-8-12(10)17-15/h1-8,17-18,20H

InChi Key：FQCPPVRJPILDIK-UHFFFAOYSA-N

Canonical SMILES：C1=CC=C2C(=C1)C(=C(N2)O)C3=C(C4=CC=CC=C4N3)N=O

Isomeric SMILES：C1=CC=C2C(=C1)C(=C(N2)O)C3=C(C4=CC=CC=C4N3)N=O

WGK Germany：3

PubChem CID：3707

DrugBank Ligand：DB02052

ChEMBL Ligand：CHEMBL126077

CAS Registry No.：160807-49-8

Reactome Reaction：R-HSA-9687724

Reactome Drug：R-ALL-9687682

溶解性：Soluble in DMSO (6 mg/ml), ethanol (4 mg/ml), DMF (~10 mg/ml), 15 DMSOPBS (pH 7.2) (0.15 mg/ml), and methanol. Insoluble in water.

个人防护装备：Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter

产品包装