产品名称

英文名称：3′-Azido-3′-deoxythymidine

同义词

zidovudine、Azidothymidine、30516-87-1、3'-Azido-3'-deoxythymidine、Retrovir、AZT、Zidovudinum、Thymidine, 3'-azido-3'-deoxy-、Compound S、Zidovudina、ZIDOVUDINE [AZT]、zidovudin、Trizivir、BW A509U、Zidovudinum [Latin]、3'-Deoxy-3'-azidothymidine、BWA509U、ZDV、BW-A509U、B、齐多夫定、叠氮胸苷、1-(3-叠氮基-2,3-二脱氧-β-D-呋喃核糖基)胸腺嘧啶

产品性质

CAS编号：30516-87-1

分子式：C10H13N5O4

分子量：267.24

Beilstein号：3595791

MDL号：MFCD00006536

PubChem编号：35370

别名：齐多夫定|叠氮胸苷|1-(3-叠氮基-2,3-二脱氧-β-D-呋喃核糖基)胸腺嘧啶

英文别名：zidovudine|Azidothymidine|30516-87-1|3'-Azido-3'-deoxythymidine|Retrovir|AZT|Zidovudinum|Thymidine, 3'-azido-3'-deoxy-|Compound S|Zidovudina|ZIDOVUDINE [AZT]|zidovudin|Trizivir|BW A509U|Zidovudinum [Latin]|3'-Deoxy-3'-azidothymidine|BWA509U|ZDV|BW-A509U|B

规格或纯度：≥98%(HPLC)

英文名称：3′-Azido-3′-deoxythymidine

生化机理：Zidovudine (Azidothymidine, AZT) is a nucleoside analog reverse-transcriptase inhibitor (NRTI), a type of antiretroviral drμg used for the treatment of HIV/AIDS infection.Nucleoside reverse-transcriptase inhibitor (NRTI). Antiretroviral, Blood brain barrier permeable.

应用：An inhibitor of HIV-1 reverse transcriptase.

储存温度：-20°C储存,充氩

运输条件：超低温冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：对 HIV-1 病毒有效的逆转录酶抑制剂An inhibitor of HIV-1 reverse transcriptase.3′-Azido-3′-deoxythymidine is an inhibitor of HIV-1 RT (HIV-1 reverse transcriptase) that blocks the incorporation of nucleotides into growing DNA strands. Useful for antiviral and anticancer studies. 3′-Azido-3′-deoxythymidine enters CNS by diffusion and causes irreversible telomere shortening.An inhibitor of HIV-1 reverse transcriptase.

IUPAC Name：1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

INCHI：InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

InChi Key：HBOMLICNUCNMMY-XLPZGREQSA-N

Canonical SMILES：CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-]

Isomeric SMILES：CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N=[N+]=[N-]

WGK Germany：3

RTECS：XP2072000

PubChem CID：35370

Reaxy-Rn：3595791

DrugBank Ligand：DB00495

Wikipedia：Zidovudine

ChEMBL Ligand：CHEMBL129

CAS Registry No.：30516-87-1

ChEBI：CHEBI10110

RCSB PDB Ligand：AZZ

PEP：zidovudine

Immunopaedia Search：zidovudine

DrugCentral Ligand：2861

溶解性：Soluble in water (50 mg/ml), DMSO, and methanol.

敏感性：对光敏感，易吸潮

比旋光度：47° (C=1,H2O)

熔点：124 °C

象形图：

信号词：Danger

危险声明：H341 Suspected of causing genetic defectsH351 Suspected of causing cancerH372 Causes damage to organs through prolonged or repeated exposureH350 May cause cancerH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P405,P501,P264,P260,P281,P270,P203,P318,P319

Merck Index：10123

个人防护装备：Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

产品包装