产品名称

英文名称：Leflunomide

同义词

HWA486、RS-34821、L 5025、leflunomide、SU 101、UNII-G162GK9U4W、HMS2235C07、HMS3371F21、lefunamide、5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide、KBio1_000916、Spectrum5_000850、HSDB 7289、5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide)、LEFLUNOM、来氟米特

产品性质

CAS编号：75706-12-6

分子式：C12H9F3N2O2

分子量：270.21

MDL号：MFCD00867593

PubChem编号：3899

别名：来氟米特

英文别名：HWA486|RS-34821|L 5025|leflunomide|SU 101|UNII-G162GK9U4W|HMS2235C07|HMS3371F21|lefunamide|5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide|KBio1_000916|Spectrum5_000850|HSDB 7289|5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide)|LEFLUNOM

规格或纯度：≥98%

英文名称：Leflunomide

生化机理：Leflunomide is an immunosuppressive drμg that inhibits T and B cell responses. Leflunomide is an inhibitor of Cox-2, of tyrosine phosphorylation (tyrosine kinase), of DHODH (dihydroorotate dehydrogenase), an enzyme for de novo pyrimidine synthesis, and of TNF-dependent NF-κB activation. The physiological activity of leflunomide is attributed mainly to its metabolite A77 1726.Immunomodulatory agent. Inhibits dihydroorotate dehydrogenase (K i = 2.7 μM). Inhibits T and B cell activity and prevents lymphocyte cell cycle proliferation and progression. Also shows anti-inflammatory activity. Active In vivo .

应用：An inhibitor of Cox-2 and tyrosine kinase.

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Leflunomide是免疫抑制剂，其活性代谢产物为A77 1726(RS-61980)。An inhibitor of Cox-2 and tyrosine kinase.Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD, used as an immunosuppressant agent.An inhibitor of Cox-2 and tyrosine kinase.

ALogP：2.5

IUPAC Name：5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide

INCHI：InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)

InChi Key：VHOGYURTWQBHIL-UHFFFAOYSA-N

Canonical SMILES：CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F

Isomeric SMILES：CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F

WGK Germany：3

RTECS：NY2354200

PubChem CID：3899

Reaxy-Rn：4323174

DrugBank Ligand：DB01097

CAS Registry No.：75706-12-6

ChEMBL Ligand：CHEMBL960

Wikipedia：Leflunomide

DrugCentral Ligand：1552

溶解性：Soluble in DMSO (54 mg/ml at 25 °C), ethanol (54 mg/ml at 25 °C), and water (<1 mg/ml at 25 °C).

敏感性：对热敏感

熔点：166.5°C

象形图：

信号词：Danger

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritationH301 Toxic if swallowed

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P270,P304+P340,P403+P233,P362+P364,P330,P264+P265,P301+P316,P337+P317,P332+P317,P319

Merck Index：5432

个人防护装备：dust mask type N95 (US), Eyeshields, Faceshields, Gloves

产品包装