产品名称

英文名称：Piroxicam

同义词

piroxicam、36322-90-4、Feldene、Piroxicamum、Pyroxycam、Roxicam、Piroftal、BAXO、CP-16171、Rosiden、CHF 1251、2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide、4-Hydroxy-2-methyl-N-(pyridin-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxamid、炎痛喜康、吡罗昔康、2-甲基-4-羟基-N-(2-吡啶基)-2H-1,2-苯并噻嗪-3-甲酰胺-1,1-二氧化物、吡啶苯噻酰胺、吡氧噻嗪

产品性质

CAS编号：36322-90-4

分子式：C15H13N3O4S

分子量：331.35

Beilstein号：1876290

EC号：252-974-3

MDL号：MFCD00057317

PubChem编号：54676228

别名：炎痛喜康|吡罗昔康|2-甲基-4-羟基-N-(2-吡啶基)-2H-1,2-苯并噻嗪-3-甲酰胺-1,1-二氧化物|吡啶苯噻酰胺|吡氧噻嗪

英文别名：piroxicam|36322-90-4|Feldene|Piroxicamum|Pyroxycam|Roxicam|Piroftal|BAXO|CP-16171|Rosiden|CHF 1251|2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide|4-Hydroxy-2-methyl-N-(pyridin-2-yl)-2H-benzo[e][1,2]thiazine-3-carboxamid

规格或纯度：≥98%(HPLC)

英文名称：Piroxicam

生化机理：Piroxicam is an effective and potent inhibitor of prostaglandin synthesis and a Cox-1 and Cox-2 inhibitor. Studies show that Piroxicam blocks release of platelet ADP, and inhibits Cox-1 (human prostaglandin H synthase isozyme-1, hPGHS-1) more potently than Cox-2 (hPGHS-2). Piroxicam is also a non-steroidal compound with anti-inflammatory properties.Reversible, selective cyclooxygenase-1 (COX-1) inhibitor. Shows 8-fold greater activity against COX-1 than COX-2 (IC 50 values are 0.76 and 8.99 μM for COX-1 and COX-2, respectively).

应用：An inhibitor of prostaglandin synthesis as well as Cox-1 and Cox-2.

储存温度：2-8°C储存,充氩

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Piroxicam 是一种非选择性COX抑制剂，IC50为6 mM。An inhibitor of prostaglandin synthesis as well as Cox-1 and Cox-2.Piroxicam is a non-selective COX inhibitor with an IC50 of 6 mM.An inhibitor of prostaglandin synthesis as well as Cox-1 and Cox-2.

IUPAC Name：4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-yl-1λ6,2-benzothiazine-3-carboxamide

INCHI：InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)

InChi Key：QYSPLQLAKJAUJT-UHFFFAOYSA-N

Canonical SMILES：CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3

Isomeric SMILES：CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3

WGK Germany：3

RTECS：DL0705000

PubChem CID：54676228

DrugBank Ligand：DB00554

CAS Registry No.：36322-90-4

ChEMBL Ligand：CHEMBL527

Wikipedia：Piroxicam

PEP：piroxicam

DrugCentral Ligand：2210

溶解性：Soluble in water (Partly miscible), DMSO (25 mg/mL warm), ethanol (5 mg/mL warm), chloroform, ethyl acetate, DMF (~20 mg/mL), and 11 solution of DMSOPBS(pH 7.2) (~0.5 mg/mL).

敏感性：对热敏感,对空气敏感

闪点(℉)：123.8 °F

闪点(℃)：51 °C

熔点：198-200°C

象形图：

信号词：Danger

危险声明：H301 Toxic if swallowedH372 Causes damage to organs through prolonged or repeated exposureH360 May damage fertility or the unborn childH361 Suspected of damaging fertility or the unborn child

预防措施声明：P280,P321,P405,P501,P264,P260,P270,P330,P203,P301+P316,P318,P319

Merck Index：7506

个人防护装备：dust mask type N95 (US), Eyeshields, Faceshields, Gloves

产品包装