产品名称

英文名称：Mevastatin

同义词

73573-88-3、Compactin、EC 700-442-0、Mevastatin、ML-236B、Mevastatinum、Mevastatina、Mevastatine、Antibiotic ML 236B、Mevastatin [INN]、Mevastatinum [INN-Latin]、Compactin (penicillium)、CS 500、ML 236 B、CCRIS 4505、Mevastatine [INN-French]、UNII-1UQM1K0W9X、Mevastatina、康帕丁、康百汀

产品性质

CAS编号：73573-88-3

分子式：C23H34O5

分子量：390.51

Beilstein号：1269441

MDL号：MFCD05662341

PubChem编号：64715

别名：康帕丁|康百汀

英文别名：73573-88-3|Compactin|EC 700-442-0|Mevastatin|ML-236B|Mevastatinum|Mevastatina|Mevastatine|Antibiotic ML 236B|Mevastatin [INN]|Mevastatinum [INN-Latin]|Compactin (penicillium)|CS 500|ML 236 B|CCRIS 4505|Mevastatine [INN-French]|UNII-1UQM1K0W9X|Mevastatina

规格或纯度：≥96%(HPLC)

英文名称：Mevastatin

生化机理：Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) (Ki for acid form is 1 nM) which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. Mevastatin suppresses TNF-induced NF-κB activation (IC50 = ~17 ?M), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer.Potent HMG-CoA reductase inhibitor. Proapoptotic, able to arrest cells in G 1 by down-regulation of CDK4, CDK6 and cyclin D1 and up-regulation of p21 and p27.

应用：3-羟基-3-甲基戊二酰-CoA还原酶（3-hydroxy-3-methylglutaryl-CoA reductase）、HMG-CoA还原酶（HMG-CoA reductase）抑制剂。

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：3-羟基-3-甲基戊二酰-CoA还原酶（3-hydroxy-3-methylglutaryl-CoA reductase）、HMG-CoA还原酶（HMG-CoA reductase）抑制剂。

IUPAC Name：[(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate

INCHI：InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1

InChi Key：AJLFOPYRIVGYMJ-INTXDZFKSA-N

Canonical SMILES：CCC(C)C(=O)OC1CCC=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O

Isomeric SMILES：CC[C@H](C)C(=O)O[C@H]1CCC=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O

WGK Germany：3

PubChem CID：64715

CAS Registry No.：73573-88-3

DrugBank Ligand：DB06693

Wikipedia：Mevastatin

ChEMBL Ligand：CHEMBL54440

RCSB PDB Ligand：2UO

密度：1.13

比旋光度：281° (C=0.4,Acetone)

熔点：153°C

象形图：

信号词：Danger

危险声明：H351 Suspected of causing cancerH373 Causes damage to organs through prolonged or repeated exposureH412 Harmful to aquatic life with long lasting effectsH317 May cause an allergic skin reactionH360 May damage fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P261,P273,P280,P302+P352,P321,P405,P501,P264,P260,P270,P272,P333+P313,P362+P364,P263,P203,P318,P319

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装