产品名称

英文名称：Andrographolide

同义词

Andrographolide、5508-58-7、CHEBI65408、HMPL004、UNII-410105JHGR、DTXSID3045980、410105JHGR、EINECS 226-852-5、(S,E)-4-Hydroxy-3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethylidene)dihydrofuran-2(3H)-on、穿心莲内酯、穿心莲

产品性质

CAS编号：5508-58-7

分子式：C20H30O5

分子量：350.45

Beilstein号：42762

EC号：226-852-5

MDL号：MFCD07778082

PubChem编号：5318517

别名：穿心莲内酯|穿心莲

英文别名：Andrographolide|5508-58-7|CHEBI65408|HMPL004|UNII-410105JHGR|DTXSID3045980|410105JHGR|EINECS 226-852-5|(S,E)-4-Hydroxy-3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethylidene)dihydrofuran-2(3H)-on

规格或纯度：98%

英文名称：Andrographolide

生化机理：NF-κB信号传导抑制剂；还减弱了伴刀豆碱诱导的鼠T细胞中IFNγ的产生（IC50 =1.7μM）。在表达AR的C4-2细胞中阻断雄激素受体（AR）的表达。响应香烟烟雾提取物，激活BEAS-2B细胞中的Nrf2。

运输条件：常规运输

备注：100mg/500mg卖完停产，不再备货

产品介绍：Andrographolide, a bioactive diterpene lactone, is the main constituent of Andrographis paniculata, a plant used in traditional medicines. It is known to have different biological activities such as anti-inflammatory, anti-malarial, anti-cancer and hepatoprotective activity. It also shows potent anti-viral effect against dengue virus植物抗菌制剂。具有抗炎特性的二萜内酯。它阻止T细胞对异体刺激带来的增殖和巨噬细胞趋化补体迁移。阻止几种癌症细胞在体外的增殖。异体刺激Andrographolide, a bioactive diterpene lactone, is the main constituent of Andrographis paniculata, a plant used in traditional medicines. It is known to have different biological activities such as anti-inflammatory, anti-malarial, anti-cancer and hepatoprotective activity. It also shows potent anti-viral effect against dengue virus

PubChem SID：488195335

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488195335

IUPAC Name：(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one

INCHI：InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1

InChi Key：BOJKULTULYSRAS-OTESTREVSA-N

Canonical SMILES：CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O

Isomeric SMILES：C[C@@]12CC[C@H]([C@@]([C@H]1CCC(=C)[C@H]2C/C=C/3\[C@@H](COC3=O)O)(C)CO)O

WGK Germany：3

RTECS：LU3490750

关联CAS：5508-58-7

PubChem CID：5318517

MeSH Entry Terms：17-hydro-9-dehydro-andrographolide;andrographolide;isoandrographolide

溶解性：溶于DMSO, 最高浓度 (mg/mL) 35.05, 最高浓度(mM) 100；溶于ethanol, 最高浓度 (mg/mL) 3.5, 最高浓度(mM) 10

密度：1.21

比旋光度：-126° (C=1.5,AcOH)

熔点：229-232°C

象形图：

信号词：Warning

危险声明：H315 Causes skin irritationH319 Causes serious eye irritationH335 May cause respiratory irritation

预防措施声明：P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

Merck Index：633

个人防护装备：Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter

产品包装